Determining Normal Range for Free Light Chains in Serum Among Twins

The objective of this study is to recruit healthy adult identical and fraternal twins for the collection of one teaspoon of blood to be sent to the Clinical Lab at San Francisco General Hospital. The serum will be tested to determine the reference range for free light chains.

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Key information

Conditions

Multiple Myeloma Blood Protein Disorders Cardiovascular Diseases Hematologic Diseases Hemic and Lymphatic Diseases Hemorrhagic Disorders Hemostatic Disorders Immune System Diseases Immunoproliferative Disorders Lymphoproliferative Disorders Neoplasms Neoplasms by Histologic Type Neoplasms, Plasma Cell Paraproteinemias Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

San Francisco General Hospital

San Francisco, California, 94306, United States

About this study

Serum free light chains are used to assist in the diagnosis of multiple myeloma. The test measures kappa (K) and lambda (L) chains, and the calculation of the ratio of kappa to lambda (K/L). Previous studies have shown that the K/L ratio does not change over time (1 year). The hypothesis of this study is that healthy twins will have a K/L ratio that are close to each other in value, suggesting that this ratio is genetically linked.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy subjects 18-80 years.
Must be an identical or fraternal twin (both must be recruited)

Exclusion criteria

Symptoms suggestive of multiple myeloma (e.g., renal insufficiency, anemia, bone pain) -

Treatment and study plan

Free light chains

Other

Blood samples will be collected and analyzed

Primary outcomes

Free light chain reference range

Time frame: One month after the completion of the enrollment

Determination of the normal range for free light chains

Sponsors and collaborators

Lead sponsor

University of California, San Francisco

Other

Registry information

Official study title

Normal Range Study for Free Light Chains in Blood Among Identical or Fraternal Twins

Important dates

Study start: 2018
Primary completion: 2024
Study completion: 2024
First posted: Dec 9, 2019
Registry last updated: Jan 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed