Determination of the Independent Effects of Beetroot Juice Components, Dietary Nitrate and Antioxidants, on Exercise Tolerance and Health Benefits in Individuals With Obesity

The purpose of this study is to assess the effects of acute beetroot juice supplementation on exercise performance and cardiometabolic health in obese individuals with secondary cardiometabolic complications. Additionally, we will determine if the ergogenic health benefits of beetroot juice is due to the nitric oxide compound within the product, the antioxidant compound within the product, or a combination of the two compounds.

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Key information

Conditions

Metabolic Disease Behavior Body Weight Exercise Metabolic Diseases Motor Activity Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

BMI ≥ 30 kg/m2
Able to perform exercise testing on a cycle ergometer

Exclusion criteria

Currently taking medications know to affect cardiovascular or respiratory function
Currently supplementing with an antioxidant compound
Current smoker
Currently taking antibiotics
Not willing to abstain from mouthwash use
Currently participating in regular physical activity

Treatment and study plan

Sodium nitrate

Dietary Supplement

70ml sodium nitrate, matched for nitrate concentration in Beetroot Juice arm

Beetroot Juice no Nitrate

Dietary Supplement

70ml Concentrated Beetroot Juice with nitrate removed

Beetroot juice

Dietary Supplement

70ml Concentrated Beetroot Juice

Primary outcomes

Time to Exhaustion

Time frame: A Time to Exhaustion Test will be conducted on each participant a total of four times throughout their participation in the study. This will take place approximately 2.5 hours post ingestion of the dietary supplement they are randomized to at each visit.

Sponsors and collaborators

Lead sponsor

University of Alabama at Birmingham

Other

Registry information

Acronym: BEETIT

Important dates

Study start: 2018
Primary completion: 2020
Study completion: 2020
First posted: Jun 4, 2018
Registry last updated: Sep 22, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed