Determination of the in Vitro Effects of Cationic Airway Lining Modulators (CALM) on Chronic Obstructive Pulmonary Disease (COPD) Sputum

This study is intended to be an evaluation of the properties of human sputum collected from patients with COPD. It is hypothesized that cationic airway lining modulators will have beneficial effects on the rheological properties of sputum derived from patients with COPD. Approximately 10 patients with COPD will collect sputum at home for 5 days. Samples will be collected and tested in laboratory tests.

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Key information

Conditions

Chronic Obstructive Pulmonary Disease Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

35 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

VA WNY Healthcare System

Buffalo, New York, 14215, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical and spirometric diagnosis of COPD
Smoking history of at least 10 pack yrs
Sputum production of greater than 2 tablespoons per day by patient report.

Exclusion criteria

a primary diagnosis of asthma or bronchiectasis
a COPD exacerbation within 4 weeks
Inability to comply with study procedures.

Sponsors and collaborators

Lead sponsor

Pulmatrix Inc.

Industry

Collaborators

Buffalo Institute For Medical Research
The VA Western New York Healthcare System

Registry information

Official study title

Determination of the in Vitro Effects of CALM on COPD Sputum

Important dates

Study start: 2010
Primary completion: 2010
Study completion: 2010
First posted: Mar 30, 2010
Registry last updated: Apr 11, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed