Determination of Carboplatin's Optimal Plasmatic Exposure

To determine Carboplatin's optimal exposures(optimal AUCs)and parameters they depend on.

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Key information

Conditions

Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre Paul Papin, Angers, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Carcinoma histologically proved and which must be treated by Carboplatin, excepted weekly administered Carboplatin treatments
Age > 18 years
Neutrophils > 1500/mm3, blood-platelets > 100000/mm3
Patient with intravenous administration route for chemotherapy independent of the one used for blood samples ( for Investigators centers achieving pharmacokinetic examination)
Well-informed written consent, signed by the patient

Exclusion criteria

Carboplatin treatment's contra-indication
Patient with clinically detectable cerebral metastasis
Pregnant or nursing women
Patient under guardianship or trusteeship
Patient whose venous status don't permit a peripheral intravenous administration route's placing (for Investigators centers achieving pharmacokinetic examination)

Treatment and study plan

carboplatin

Drug

Primary outcomes

To determine Carboplatin's optimal exposures (optimal AUCs) and parameters they depend on.

Secondary outcomes

To assign a standardization method for Carboplatin doses's calculation in chemotherapy's protocol including this drug.

Sponsors and collaborators

Lead sponsor

Institut Claudius Regaud

Other

Registry information

Important dates

Study start: 2005
Primary completion: 2007
Study completion: 2009
First posted: Sep 5, 2005
Registry last updated: Mar 18, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed