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Completed

NCT Number: NCT02806089

Determinants of Muscle Strength in Chronic Kidney Disease

Aim of this study is to determine in chronic kidney disease patients:

* the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment * the relationship between voluntary muscle strength and muscle mass * the relationship between voluntary muscle strength and lean body mass * the correlation between voluntary muscle strength and physical activity

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Key information

Conditions

Chronic Kidney Disease Behavior Chronic Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Motor Activity Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

AIDER, Montpellier, France

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About this study

Aim of this study is to determine in chronic kidney disease patients:

  • the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment (estimated by handheld dynamometer)
  • the relationship between voluntary muscle strength and muscle mass (estimated by creatinine index)
  • the relationship between voluntary muscle strength and lean body mass (estimated by bioelectrical impedance analysis)
  • the correlation between voluntary muscle strength and physical activity (the physical activity being estimated by the "Voorrips" score questionnaire)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • chronic kidney disease patient with extrarenal replacement therapy by hemodialysis for at least 3 months
  • stable clinical condition (absence of infection, stroke or acute decompensation)

Exclusion criteria

  • chronic kidney disease without extrarenal replacement therapy
  • history of renal transplantation

Treatment and study plan

Handheld dynamometer

Device

Evaluation of muscle strength

Creatinine index

Biological

Evaluation of muscle mass using plasma creatinine level

Electrical bioimpedance analysis

Device

Evaluation of lean body mass

"Voorrips" score questionnaire

Other

Evaluation of physical activity

Inflammatory and nutritional status

Biological

Evaluation of C reactive protein and albumin

Primary outcomes

  1. Voluntary muscle strength evaluated by handheld dynamometer

    Time frame: 1 day

    data will be measured in Newton.meter

Secondary outcomes

  1. Muscle mass estimated by creatinine index evaluation

    Time frame: 1 day

    data will be obtained from plasma creatinine level and will be expressed in milligram/kilogram/day)

  2. Lean body mass evaluated by electrical bioimpedance analysis

    Time frame: 1 day

    data will be expressed in kilogram

  3. Physical activity estimated using the "Voorrips" score questionnaire

    Time frame: 1 day

    the score represents the daily physical activity according to a validated scale

  4. C reactive protein level

    Time frame: 1 day

    the parameter will be measured in milligram/liter

  5. Albumin level

    Time frame: 1 day

    the parameter will be measured in gram/liter

Sponsors and collaborators

Lead sponsor

University Hospital, Montpellier

Other

Registry information

Important dates

Study start
2016
Primary completion
2017
Study completion
2017
First posted
Jun 20, 2016
Registry last updated
Feb 28, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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