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Completed

NCT Number: NCT03305900

Determinants of Formate Concentrations

Formate is an important metabolite, serving as a donor of one-carbon groups to the intracellular tetrahydrofolate pool. However, little is known of its circulating concentrations or of their determinants. This study seeks to define formate levels and their determinants in a young, healthy population.

Serum formate will be measured in 1701 subjects from the Trinity Student Study. The subjects, males and females, aged 18 to 28 years, were enrolled at Trinity College, Dublin. Formate levels will be compared with other one-carbon metabolites, vitamin status, potential formate precursors, genetic polymorphisms, and lifestyle factors.

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Key information

Conditions

Healthy

Age range

18 year–28 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Trinity College Dublin students with Irish grandparents

Exclusion criteria

  • None

Treatment and study plan

No intervention

Other

Cross-sectional study requiring a single serum sample

Primary outcomes

  1. Formate concentrations

    Time frame: Single baseline measurement; cross sectional, observational study

    Formate concentrations in study population

Sponsors and collaborators

Lead sponsor

Memorial University of Newfoundland

Other

Collaborators

  • University of Dublin, Trinity College

Registry information

Official study title

Lifestyle, Metabolite and Genetic Determinants of Formate Concentrations in a Cross-sectional Study of Young, Healthy Adults

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Oct 10, 2017
Registry last updated
Oct 10, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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