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NCT Number: NCT07231198

Detection of Microplastics in Patients With Periodontitis

Plastic particles known as microplastics are now a ubiquitous part of the environment. Human exposure to microplastics occurs through the consumption of contaminated food and polluted air, which affect the intestinal system. Several studies have detected the presence of microplastics in various parts of the human digestive system, e.g., in feces. Unfortunately, little is known about the presence of microplastics in the mouth as the primary part of the digestive system. Periodontal pockets can be considered an ideal deposition site for microplastics. Since microplastics are suspected of being an immunomodulatory factor, there is great interest in their presence in subgingival plaque and their possible exacerbation of chronic inflammatory diseases such as periodontitis. The following study aims to clarify the presence, classification, and concentration of microplastics in subgingival plaque. No comparable study has been identified to date.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 and over
  • Gender: Female / male / diverse
  • Patients
  • who have been diagnosed with stage III and IV periodontitis.
  • who have not yet started periodontal treatment.
  • who still have at least 20 teeth. Providing written consent to participate in the study.

Exclusion criteria

  • Patients
  • who have already been treated for periodontitis
  • who have already undergone/begun periodontitis treatment

Treatment and study plan

Primary outcomes

  1. Microplastics

    Time frame: one year

    number of patients with periodontitis with microplastics in periodontal pockets, quantification of microplastic particles in periodontal pockets, qualitative analysis of microplastic

Study contacts

Contact information is provided by the study sponsor or research team.

Hady Haririan, Univ.-Prof., Dr., PhD, MSc

CONTACT

[email protected]

+4317201966

Sponsors and collaborators

Lead sponsor

Sigmund Freud PrivatUniversitat

Other

Registry information

Official study title

Detection of Microplastics in Patients With Periodontitis - a Cross-sectional Study

Acronym: micropl_perio

Important dates

Study start
2026
Primary completion
2027
Study completion
2028
First posted
Nov 17, 2025
Registry last updated
Nov 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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