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Completed

NCT Number: NCT00636844

Detection of Chemotherapy Induced Cardiotoxicity

To identify patients that are at risk of heart damage after receiving chemotherapy (adriamycin).

Completed

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Key information

Conditions

Cancer Cardiotoxicity Cardiovascular Diseases Chemically-Induced Disorders Drug-Related Side Effects and Adverse Reactions Heart Diseases Neoplasms Pathologic Processes Pathological Conditions, Signs and Symptoms Radiation Injuries Wounds and Injuries

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

George Washington University

Washington D.C., District of Columbia, 20037, United States

About this study

To identify patients at risk of development of heart damage after receiving chemotherapy by obtaining the genetic profile of those who show: elevation of troponin, left ventricular systolic and diastolic dysfunction, and pro-oxidant stress markers.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • undergoing anthracycline and/or trastuzumab therapy for the first time

Exclusion criteria

  • abnormal ventricular ejection fraction
  • past history of, or active cardiac disease including: MI, CHF, angina, arrhythmia requiring medication, valvular disease, uncontrolled systemic hypertension

Treatment and study plan

Primary outcomes

  1. The genetic profile of patients with anthracycline-induced elevation of troponin-I

    Time frame: one year

Secondary outcomes

  1. Assess the genetic profile of patient with anthracycline-induced left ventricular systolic and diastolic dysfunction

    Time frame: one year

  2. Assess the relationship of quantitative increases of pro-oxidant stress and a specific genetic profile

    Time frame: one year

Sponsors and collaborators

Lead sponsor

George Washington University

Other

Registry information

Important dates

Study start
2008
Primary completion
2011
Study completion
2012
First posted
Mar 17, 2008
Registry last updated
Mar 13, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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