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OpenTrials
Completed

NCT Number: NCT02760524

Desensitizing Distressing Recollections in Cancer Patients

The major goal of this study is to determine whether Neuro-Emotional Technique is a viable treatment option for decreasing distress in cancer patients. The potential advantages of NET are: 1) it is designed specifically to address distressing stimuli and unresolved emotional memories; 2) it is a brief, time-limited intervention; and 3) its multi-modal design may appeal to and benefit a broader range of patients than a single mode intervention

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Key information

Conditions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Thomas Jefferson University

Philadelphia, Pennsylvania, 19107, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18 years of age
  • Distressing cancer-related recollection that has persisted for at least six months
  • Distressing cancer-related recollection that causes physiological reactivity (i.e., increased heart rate and/or increased skin conductance level - SCL), as described in section 4.2.3.
  • Received a cancer diagnosis at least 6 months prior to being contacted for participation in this study

Exclusion criteria

  • Any current Major Mental Disorder, as assessed by Structured Clinical Interview for DSM IV Axis I Disorders (SCID - Clinical Version, First et al, 1997)
  • History of Post-traumatic Stress Disorder
  • Current active mood primary disorder prior to the cancer diagnosis (as per PI or designate)
  • History or current diagnosis of substance or alcohol abuse or dependence (as per PI or designate)
  • Use of psychotropic medications within the past month or current use of medications that would interfere with autonomic nervous system measures (benzodiazepines, barbiturates, major tranquilizers).
  • Use of some psychotropic medications are allowed such as SSRIs and certain sleep aids, but dosages must be stable from six weeks prior to enrollment and throughout study period
  • Any psychological or musculoskeletal problems that would interfere with psychophysiological assessments and treatment
  • Currently receiving chemotherapy or radiation
  • Are in the terminal stages of illness

Treatment and study plan

NET Intervention

Behavioral

Neuro-emotional Technique

Primary outcomes

  1. Post traumatic Cognitions Inventory

    Time frame: baseline/ 4 weeks/6 months follow up

    change from baseline Post Traumatic Cognitions Inventory score

  2. State Trait Anxiety Inventory

    Time frame: baseline/4 weeks/6 months follow up

    change from baseline State Trait Anxiety Inventory score

  3. Brief Symptom Inventory

    Time frame: baseline/4 weeks/6 month follow up

    change from baseline Brief Symptom Inventory

Secondary outcomes

  1. Autonomal response to distressing recollections

    Time frame: baseline/4 weeks follow up

    change from baseline in autonomal response to distressing recollections

  2. Genomic testing

    Time frame: baseline/ 4 weeks follow up

    change from baseline genomic testing before and after intervention

Sponsors and collaborators

Lead sponsor

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

Other

Registry information

Acronym: NET

Important dates

Study start
2010
Primary completion
2015
Study completion
2017
First posted
May 3, 2016
Registry last updated
May 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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