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Completed

NCT Number: NCT04786561

Depression, Anxiety and Social Relationships as Risk Factors for Dementia

The main objective of the present work is to establish a firm knowledge base regarding depression and anxiety as risk factors for dementia and how social relationships impact this association. This risk factors, and efforts to reduce them are described through a follow up over three decades.

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Key information

About this study

The Health Study in Nord-Trondelag (HUNT) fulfils most of the key requirements of a population-representative cohort study by meeting the following elements: firm knowledge about the population denominator, knowledge about reasons for refusal (in line with previous methods in HUNT), options for levels and localisation of participation (at test station, at home, at nursing homes), coverage of sociodemographic features by the comprehensive HUNT4-protocol and register linkage, inclusion of institutionalized individuals and individuals with reduced capacity to consent, measurement of risk and compensatory factors across the life course by merging with previous results in HUNT surveys and linkage to registries, core elements and assessment methods can be compared with other European populations studies including elderly people, and finally, the ability to include biobank results in the data analysis. The HUNT data supplemented by register linkage include all established and suspected risk factors of dementia.

A particular focus on primary health care is appropriate because it is in this part of the health care system that the need for extra resources due to the substantial increase in dementia prevalence is most pronounced. Furthermore, preventive measures in a life-course perspective will mainly have to be implemented in the primary health care setting.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Living in designated area

Exclusion criteria

  • None

Treatment and study plan

Primary outcomes

  1. Incidence of dementia diagnosis in HUNT4 70+ study

    Time frame: 2017-2019

    Two clinical and scientific experts will independently set at diagnosis of cognitive impairment or dementia based on all available information applying standard diagnostic criteria DSM-5.

  2. Incidence of Minimal Cognitive Impairment (MCI) in the HUNT 70+ study

    Time frame: 2017-2019

    Two clinical and scientific experts will independently set at diagnosis of cognitive impairment or dementia based on all available information applying standard diagnostic criteria DSM-5.

Secondary outcomes

  1. Change in loneliness

    Time frame: 1995-2019

    Self-reported feeling of loneliness

Sponsors and collaborators

Lead sponsor

Norwegian Centre for Ageing and Health

Other

Collaborators

  • Norwegian Health Association
  • Norwegian Institute of Public Health
  • Norwegian University of Science and Technology
  • University College, London

Registry information

Official study title

Depression as Risk Factor for Dementia

Important dates

Study start
2020
Primary completion
2024
Study completion
2024
First posted
Mar 8, 2021
Registry last updated
Mar 22, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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