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OpenTrials
Completed

NCT Number: NCT03091153

Deprescribing in a Long Term Care Facility

This study will develop, implement and evaluate a deprescribing initiative at a Canadian Long Term Care (LTC) Facility. Residents currently undergo an annual medication review as part of the clinical pharmacy services provided in the LTC facility. For this study, eligible residents will be randomized to receive either a deprescribing focused medication review or usual care.

The deprescribing focused medication therapy assessments will be done on half of the 143 residents residing on the second and third floors of the facility. The other half of residents will serve as the control group and continue to receive their annual medication review and regular care from the attending physicians and nurses.

The deprescribing intervention will be delivered by final year pharmacy students completing their practice experiences, under the supervision of clinical pharmacists at the LTC facility and clinical pharmacists from Memorial University's Medication Therapy Services (MTS) Clinic. Currently the clinic has a well developed procedure for providing in depth medication therapy reviews for residents of the community, upon referral by their primary care physician. Students will adapt this model of medication review to have a stronger deprescribing focus and be applicable to elderly residents of a LTC facility. The intervention will consist of an in depth medication therapy review with a focus on identifying any medications that may no longer be required or are deemed to be inappropriate or potentially unsafe in the elderly based on currently guidelines/criteria. The students will work closely with members of the resident's care team on a daily basis, as well as the resident and their family, to develop and implement a deprescribing plan.

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Key information

Conditions

Age range

65 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

St Patrick's Mercy Home

St. John's, Newfoundland and Labrador, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

(all of the following):

  • Over 65 years of age
  • Reside in St. Patrick's Mercy Home (2nd or 3rd floor units)

Exclusion criteria

(any of the following):

  • Do not take any regularly scheduled medications
  • Are receiving palliative care
  • Resident's physician or nursing team do not support participation
  • Resident or their substitute decision maker decline participation

Treatment and study plan

Medication review

Other

In depth medication review with a focus on deprescribing

Primary outcomes

  1. Change in number of medications taken daily by residents

    Time frame: 3 and 6 months after receiving intervention

    Measured using facility medication logs and patient health records

Secondary outcomes

  1. All cause mortality rate

    Time frame: 3 and 6 months after receiving the intervention

    Measured using patient health records

  2. Instance of falls in the last 30 days

    Time frame: 3 and 6 months after receiving the intervention

    Measured using facility fall report logs

  3. Frequency of emergency room visits, unplanned hospital admission and/or unplanned GP visits

    Time frame: 3 and 6 months after receiving the intervention

    Measured using patient health records

  4. Cognitive function score

    Time frame: 3 and 6 months after receiving the intervention

    Measured using Cognitive Performance Scale (CPS) obtained from Resident Assessment Instrument (RAI) MDS 2.0

  5. Bowel function

    Time frame: baseline, 3 and 6 months after receiving the intervention

    Measured using bowel chart data for the 14 days prior to the assessment date

  6. Independence in activities of daily living

    Time frame: 3 and 6 months after receiving the intervention

    Measured using the Activities of Daily Living Scale (ADL) obtained from RAI MDS 2.0

  7. Changes in general health

    Time frame: 3 and 6 months after receiving the intervention

    Measured using the Changes in Health, End-Stage Disease and Signs and Symptoms (CHESS) Score obtained from RAI MDS 2.0

  8. Social engagement

    Time frame: 3 and 6 months after receiving the intervention

    Measured using Index of Social Engagement (ISE) Score obtained from RAI MDS 2.0

  9. Aggressive behaviour

    Time frame: 3 and 6 months after receiving the intervention

    Measured using the Aggressive Behaviour Scale (ABS) obtained from RAI MDS 2.0

  10. Frequency of pain

    Time frame: 3 and 6 months after receiving the intervention

    Measured using the Pain Scale obtained from RAI MDS 2.0

Sponsors and collaborators

Lead sponsor

Memorial University of Newfoundland

Other

Collaborators

  • Eastern Health

Registry information

Official study title

Impact of a Deprescribing Intervention on Nursing Home Residents: a Randomized Controlled Trial

Important dates

Study start
2017
Primary completion
2018
Study completion
2019
First posted
Mar 27, 2017
Registry last updated
Jul 22, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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