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NCT Number: NCT07641322

Dentin Hypersensitivity in Orthodontic Patients: Triple-Blinded, Randomized Trial of Three Desensitizing Agents.

The effect of desensitizing agents will be studied on dentin hypersensitivity in orthodontic patients.it is a randomized controlled trial. three experimental groups and one placebo group.

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Key information

Conditions

Dentin Desensitizing Agents

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Orthodontic patients aged 18-40 years.
  • Presence of mild to moderate dentin hypersensitivity (VAS ≥ 4).
  • Willingness to comply with a 12-week follow-up period.
  • No active periodontal disease or untreated caries.
  • Not pregnant or breastfeeding.
  • No history of allergy to desensitizing agents

Exclusion criteria

  • o Patients with systemic conditions affecting oral health (e.g., diabetes, immunocompromised).
  • Patients using medications that affect tooth sensitivity (e.g., anti-inflammatory drugs).

Treatment and study plan

TOOTH PASTE(NHA)

Other

TOOTH PASTES CONTAINING NHA.

TOOTH PASTE (NOVAMIN)

Other

TOOTH PASTE CONTAINING NOVAMIN

TOOTH PASTE (PROARGIN)

Other

TOOTH PASTE CONTAINING PROARGIN.

TOOTH PASTE ( NON DESENSITIZING)

Other

TOOTH PASTE A NON-DESENSITIZING CONTROL

Primary outcomes

  1. REDUCTION IN DENTIN HYPERSENSITIVITY

    Time frame: 8 WEEKS

    Change in dentin hypersensitivity scores from baseline to 8 weeks using the Visual Analog Scale (VAS) and Schiff Cold Air Sensitivity Scale.

Study contacts

Contact information is provided by the study sponsor or research team.

FATIMA KHALID, BDS

CONTACT

[email protected]

03128287657

Sponsors and collaborators

Lead sponsor

Nishtar Medical University

Other

Registry information

Official study title

Dentin Hypersensitivity: Triple-Blinded, Multicenter Randomized Trial of Three Desensitizing Dentifrices vs Non-Desensitizing Control

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 11, 2026
Registry last updated
Jun 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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