Dental Safety Profile of High-Dose Radioiodine Therapy

We aim to assess the incidence of oral and dental adverse events after high-dose radioiodine therapy for differentiated thyroid cancer.

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Key information

Conditions

Thyroid Cancer Endocrine Gland Neoplasms Endocrine System Diseases Head and Neck Neoplasms Mouth Diseases Neoplasms Neoplasms by Site Salivary Gland Diseases Sialadenitis Stomatognathic Diseases Thyroid Diseases Thyroid Neoplasms Xerostomia

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital

Basel, 4031, Switzerland

About this study

Sialadenitis and xerostomia are the most frequent adverse events of high-dose radioiodine therapy. Saliva has vital functions in maintaining periodontal and oral health. Therefore, xerostomia not only impairs quality of life permanently, but may also increase the risk of caries and tooth extractions. Nevertheless, despite more than 6 decades of radioiodine therapy for thyroid cancer, large studies on long-term oral adverse events are still lacking. In the present study, we investigate the influence of high-dose radioiodine therapy on the long-term oral health.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

histologically confirmed differentiated thyroid cancer
status after total thyroidectomy
status after subsequent high-dose radioiodine treatment
regular follow-up by a board-certified dentist
a minimum follow-up of 1 year after radioiodine therapy.

Exclusion criteria

anaplastic thyroid cancer

Treatment and study plan

Radioiodine

Drug

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Official study title

The Dental Safety Profile of High-Dose Radioiodine Therapy for Thyroid Cancer

Important dates

Study start: 2004
Study completion: 2006
First posted: Feb 23, 2007
Registry last updated: Nov 14, 2007

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed