Dental Plaque Prevention Efficacy of a Stannous Fluoride Toothpaste

This two-week, randomized, double-blind, parallel-group study evaluated plaque prevention following dental cleaning. Subjects meeting plaque qualification criteria underwent a complete prophylaxis and were randomized to either a stannous fluoride test dentifrice or a sodium fluoride control dentifrice. Subjects brushed twice daily for two minutes with the assigned product. Plaque accumulation was assessed at baseline, after one day of use, and after 14 days of use following overnight abstention from oral hygiene. Plaque was disclosed and scored on facial and lingual tooth surfaces using the Lobene-Soparkar modified Turesky Plaque Index. Treatment comparisons were performed using ANCOVA with baseline plaque as a covariate.

Inclusion criteria

• Good general health based on medical history
• Minimum of 18 natural teeth with scorable surfaces
• Baseline mean plaque score ≥2.0
• Willing to refrain from non-study oral hygiene products
• Willing to abstain from oral hygiene prior to study visits
• Able and willing to comply with study procedures

Exclusion criteria

• Known allergy to oral care products
• Conditions limiting normal brushing
• Significant medical conditions affecting study participation
• Pregnant or nursing females
• Severe periodontal disease
• Recent dental prophylaxis
• Recent participation in another dental study