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NCT Number: NCT07629518

Democratizing Access to Cleaner Residential Air

The purpose of this research study is to determine whether the use of in-home air filtration to reduce exposure to air pollution benefits health.

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Key information

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

About this study

Conduct a randomized crossover pilot trial with 66 participants to calculate preliminary effect size estimates to inform a larger crossover efficacy trial:

We will: 1) enroll 66 individuals living in low and high traffic areas in Hartford (N=44) and a highly polluted urban areas in Boston Chinatown (N=22); and 2) install full filtration DIYAPs and sham DIYAPs for 30 days each in a randomized crossover trial design with a 14-day wash-out in between; and 3) measure seated and ambulatory BP, administer the SF-12v2, the Trail Making Test Part B, collect blood, and measure both indoor and outdoor PM (in size bins).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age 40 years or older Speaks English, Vietnamese, and/or Chinese Cognitive capacity to respond to questionnaires Lives fulltime at the current address, adjacent (< 200 meters) to roadways with large traffic volumes Must have one or more risk factors (hypertension or elevated blood pressure, pre-diabetes or diabetes or elevated blood sugar levels, elevated cholesterol levels, body mass index 25 or greater)

Exclusion criteria

Pregnant Works between the hours of 10 PM and 6 AM Sources of smoke in the living space (such as candles, incense, marijuana, wood stove, fireplace) almost every day/every day.

Every day exposure to motor vehicle exhaust (from cars, trucks, buses, trains), including heavy street or highway traffic.

Currently smoking or vaping Others smoking or vaping indoors, in the living space. Within the past 5 years, a diagnosis of heart attack, heart disease, stroke, blood clots or pulmonary embolism, cancer requiring surgery and/or chemo/radiation therapy

Treatment and study plan

Portable air purifiers with HEPA filtration

Other

Portable air purifiers filter air and reduce exposure to air pollutants, in this case, airborne particulate matter

Portable air purifiers without filtration (sham)

Other

Air purifiers with filters removed (sham)

Primary outcomes

  1. Blood pressure

    Time frame: Day 0, 30, 45, and 75

    Periferal blood pressure, seated

Secondary outcomes

  1. IL-1beta

    Time frame: Day 0, 30, 45, and 75

    Blood inflammatory biomarker

Study contacts

Contact information is provided by the study sponsor or research team.

Doug Brugge, PhD

CONTACT

[email protected]

18606748814

Sponsors and collaborators

Lead sponsor

Douglas Brugge

Other

Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

Registry information

Acronym: DACRA

Important dates

Study start
2026
Primary completion
2028
Study completion
2029
First posted
Jun 5, 2026
Registry last updated
Jun 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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