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NCT Number: NCT07606742

Delivery of a Culturally Tailored Exercise Training Intervention for Hispanics With Multiple Sclerosis

The purpose of this study is to establish differences in the primary outcome of walking dysfunction using the 12-Item Multiple Sclerosis Walking Scale (MSWS-12) and to establish differences in the secondary outcome of HRQoL using the 29-Item Multiple Sclerosis Walking Scale (MSWS-29) between the exercise training intervention condition and the waitlist control condition following the 16-week intervention period.

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Key information

Conditions

Multiple Sclerosis Autoimmune Diseases Autoimmune Diseases of the Nervous System Demyelinating Autoimmune Diseases, CNS Demyelinating Diseases Immune System Diseases Nervous System Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of MS
  • relapse-free in the past 30 days
  • self-identify as Hispanic/Latino
  • Patient Determined Disease Steps Scale (PDDS) score between 3.0 (gait disability) and 6.0 (bilateral support) indicates walking disability.
  • MSWS-12 score between 25 and 75, indicating walking disability
  • Willingness to complete the questionnaires and undergo randomization
  • English or Spanish as a primary language

Exclusion criteria

  • significant exercise-related risk factors or contraindications, assessed individually using the Physical Activity Readiness Questionnaire (PAR-Q; requires clearance from physician).

Treatment and study plan

Exercise Training

Behavioral

Participants will then be mailed exercise materials in their preferred language, including the program manual, logbook, calendar, newsletters, Fitbit, and resistance bands, along with instructions for telephone or video conference calls. This is a 16-week, home-based program, supported remotely via Internet-based behavioral coaching, which integrates behavior change techniques based on Social Cognitive Theory (SCT)

Primary outcomes

  1. Change in walking ability as assessed by the 12-Item Multiple Sclerosis Walking Scale (MSWS-12)

    Time frame: Baseline, 16 weeks, 32 weeks

    This is a 12 item questionnaire and each is scored on a 5-point Likert scale from 1(not at all) to 5(extremely). Total raw scores ranging from 12-60 are converted into standardized scores from 0-100, with higher scores indicating greater perceived walking impairment related to multiple sclerosis.

Secondary outcomes

  1. Change in HRQoL as assessed by the 29-Item Multiple Sclerosis Walking Scale (MSWS-29)

    Time frame: Baseline, 16 weeks, 32 weeks

    This is a 29 item questionnaire and each is scored from 1( not at all) to 5(extremely) , with a Raw score range from 29 to 145. This is then converted into a standardized scale from 0 to 100, with higher scores indicating worse walking impairment and greater impact of multiple sclerosis on mobility.

Study contacts

Contact information is provided by the study sponsor or research team.

Najha Black

CONTACT

[email protected]

713-500-9154

Stephanie L Silveira, PhD

CONTACT

[email protected]

(713) 500-9490

Sponsors and collaborators

Lead sponsor

The University of Texas Health Science Center, Houston

Other

Collaborators

  • National Institutes of Health (NIH)

Registry information

Acronym: VAMOS-MS

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
May 26, 2026
Registry last updated
May 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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