Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07583836

DELAYED VERSUS EARLY SURGICAL DECOMPRESSION FOR TRAUMATIC SPINAL CORD INJURY

To compare the outcome of early versus delayed surgical decompression among patients presenting with traumatic spinal cord injury in a tertiary care hospital.

Recruiting

Interested in participating?

Request Info

Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

About this study

Despite the increasing advocacy for early surgery, significant variability persists in clinical practice. This inconsistency stems from conflicting evidence in the literature, with some studies reporting substantial neurological benefits from early intervention, while others find no significant difference compared to delayed surgery. Similarly, in our institute, both early and delayed decompressions are in practice, whichever considered suitable by the experts. But no study has done to date that compare the outcome of both techniques. Given these gaps, there is a pressing need for a comprehensive evaluation of the existing evidence to determine the optimal timing of surgical intervention for acute traumatic SCI especially among our local population where past evidence is scarce. So, this study seeks to contribute to this critical discourse by systematically evaluating the impact of early versus delayed surgical decompression on clinical outcomes in our local population. The study would not only add evidence to the global and local data but would also help the surgeons to choose the better technique in future as the technique with better outcome would be preferred in future among all the local patients who will present to our hospital with acute SCI. Adopting the treatment strategy with better outcome would also help to reduce the overall morbidity associated with a cute SCI in our local population.

Finally objectives are , to compare the outcome of early versus delayed surgical decompression among patients presenting with traumatic spinal cord injury in a tertiary care hospital.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients presenting with spinal cord injury (both cervical and thoracic) as per described in the operational definition
  • Age from 18-60 years
  • Both male and female patients

Exclusion criteria

  • Patients with penetrating spinal injuries such as gunshot/stab wounds
  • Patients with pre-existing neurological conditions like myelopathy etc.
  • Patients with any kind of malignancy
  • Patients having CSF infection etc.
  • Patients who are not fit for general anesthesia (i.e. ASA Grade >2 Annexure-B)
  • Diagnosis of subclinical or clinical polyneuropathy
  • Non-traumatic or pathological fractures or cord compression
  • Inability to cooperate with preoperative physical examination because of cognitive impairment
  • Patients with previous spinal column or SCI.

Treatment and study plan

Early Surgical Decompression

Procedure

it will be defined as the surgical decompression performed within 24 hours of injury. It will be performed among all the patients who presented within 24 hours of injury.

Delayed Surgical Decompression

Procedure

It will be defined as the surgical decompression performed after 24 hours of spinal cord injury. It will be performed among all the patients who needed it due to medical optimization (such as hemodynamically unstable, shock, pulmonary contusions, cerebrovascular destabilization etc.) or those who will present after 24 hours of injury due to logistical delay.

Primary outcomes

  1. improvement in neurological impairment using ASIA Impairment Scale (AIS)

    Time frame: 12 Weeks after surgery

    Treatment outcomes will be measured 12 weeks after early or delayed surgical decompression among all the patients who underwent spinal cord injury in terms of improvement in neurological impairment using ASIA Impairment Scale (AIS) attached as annexure-C. Outcome will be labelled as good if shows improvement for at least two AIS grades.

Study contacts

Contact information is provided by the study sponsor or research team.

Dr. Salman Tahir, MBBS

CONTACT

[email protected]

+92 322 6192355

Sponsors and collaborators

Lead sponsor

Fauji Foundation Hospital

Other

Registry information

Official study title

COMPARISON OF DELAYED VERSUS EARLY SURGICAL DECOMPRESSION FOR TRAUMATIC SPINAL CORD INJURY

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
May 13, 2026
Registry last updated
May 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.