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OpenTrials
Completed

NCT Number: NCT05916183

Dehydration Cognition

The investigators want to understand the impact of the body losing and gaining water on brain function. Participants will restrict fluids consumed and exercise to lose 5% of body mass. Participants will then be provided fluid equal to the volume lost to consume over 2 hours (recovery). A series of brain function tests will be performed at baseline, following weight loss, and following recovery.

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Key information

Age range

18 year–26 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University at Buffalo

Buffalo, New York, 14214, United States

About this study

A baseline series of brain function tests will be performed. Following this, participants will complete a 24 hour fluid and water rich food restriction on the day proceeding testing. Participants will then complete moderate to high intensity exercise in a hot/humid room to achieve 5% body mass loss. Once baseline core body temperature returns to baseline levels, the series of brain function tests will be performed. Participants will then consume a sports drink equal to the volume of sweat lost over the course of a 2 hour recover period. Following this, he series of brain function tests will be performed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy
  • Recreationally active
  • 18-26 years old

Exclusion criteria

  • History of cardiovascular, metabolic, respiratory, neural, or renal disease
  • Hypertensive (systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90 mmHg) or tachycardic (resting heart rate ≥ 100 bpm) during the screening visit
  • Taking medication or supplements with a known side effect of affecting physiological responses to exercise (e.g., aspirin, acetaminophen, beta blockers, statins, stimulants, depressants, SSRIs)
  • Tobacco or nicotine use in the past six months
  • Current or past musculoskeletal injury impacting physical activity
  • Study physician discretion based on any other medical condition or medication

Treatment and study plan

Fluid loss and consumption

Behavioral

Upon 5% body mass loss, rehydration of fluid lost to sweating throughout a 2 hour recovery period

Primary outcomes

  1. Multitasking test

    Time frame: Upon completion of 5% body mass loss protocol, approximately 2 hours into the trial

    Accuracy score of a multitasking test (0-100%) with greater scores indicating a better outcome

  2. Multitasking test

    Time frame: 2 hours following the dehydration cognitive function test, approximately 4.5 hours into the trial

    Accuracy score of a multitasking test (0-100%) with greater scores indicating a better outcome

Sponsors and collaborators

Lead sponsor

State University of New York at Buffalo

Other

Registry information

Official study title

Impact of Dehydration and Rapid Rehydration on Cognitive Function

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Jun 23, 2023
Registry last updated
Sep 19, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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