Definitive Hypofractionated Intensity-modulated Radiation Theraphy With Concurrent Chemotherapy in Cervical Cancer

Patients receive weekly cisplatin at 40 mg/m² intravenously on days 1, 8, 15, 22, and 29, concurrently with external beam radiotherapy (EBRT). EBRT is delivered to the pelvic nodal regions at 1.8-2.0 Gy per fraction up to a total dose of 40-50 Gy. Sequential EBRT boost of 10-20 Gy to grossly positive nodal disease or 5-10 Gy to the parametrium may be applied if needed. The overall treatment course lasts approximately 7-8 weeks, and intracavitary brachytherapy (ICR) may be additionally performed when indicated.

Inclusion criteria

• Histologically confirmed cervical cancer (squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma)
• FIGO stage IIB-IVA (2018)
• Measurable primary tumor on pelvic MRI within 30 days prior to treatment initiation
• Age ≥ 20 years
• ECOG performance status 0-1
• Adequate bone marrow function: WBC ≥ 3,000/µL, ANC ≥ 1,000/µL, platelets ≥ 100,000/µL, hemoglobin ≥ 9 g/dL
• Adequate renal function: Creatinine < 2.0 mg/dL
• Ability to provide written informed consent

Exclusion criteria

• Patients with distant metastasis
• Patients who have previously received pelvic radiotherapy
• Patients who have previously received definitive chemotherapy or chemoradiotherapy for diagnosed cervical cancer
• Patients who have undergone surgery for the current cervical cancer lesion
• Patients who underwent local excisional procedures of the cervix such as conization or Loop Electrosurgical Excision Procedure (LEEP) prior to radiotherapy
• Patients who are unable to undergo concurrent chemoradiotherapy due to poor general condition
• Patients with other active malignancies (except carcinoma in situ of the cervix, basal cell carcinoma of the skin, or superficial bladder cancer) within 3 years prior to enrollment or who experienced recurrence within 3 years after treatment