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OpenTrials
Completed

NCT Number: NCT05538793

Deep Learning for the Discrimination Among Different Types of Keratits: a Nationwide Study

Detecting the cause of keratitis fast is the premise of providing targeted therapy for reducing vision loss and preventing severe complications. Due to overlapping inflammatory features, even expert cornea specialists have relatively poor performance in the identification of causative pathogen of infectious keraitis. In this project, the investigators aim to develop an automated and accurate deep learning system to discriminate among bacterial, fungal, viral, amebic and noninfectious keratitis based on slit-lamp images and evaluated this system using the datasets obtained from mutiple independent clinical centers across China.

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Key information

Age range

1 week–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ningbo Eye Hospital, Ningbo, Zhejiang, China

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Slit-lamp images with sufficient diagnostic certainty and showing keratitis at the active phase.

Exclusion criteria

  • Poor-quality images
  • Images presenting mixed infections (i.e., cornea infected by two or more causative pathogens)

Treatment and study plan

Primary outcomes

  1. Area under the receiver operating characteristic curve of the deep learning system

    Time frame: 2020-2022

Secondary outcomes

  1. Accuracy of the deep learning system

    Time frame: 2020-2022

  2. Sensitivity of the deep learning system

    Time frame: 2020-2022

  3. Specificity of the deep learning system

    Time frame: 2020-2022

Sponsors and collaborators

Lead sponsor

Ningbo Eye Hospital

Other

Registry information

Official study title

Deep Learning for the Discrimination Among Bacterial, Fungal, Viral, Amebic and Noninfectious Keratitis: a Nationwide Study

Important dates

Study start
2020
Primary completion
2023
Study completion
2023
First posted
Sep 14, 2022
Registry last updated
Oct 27, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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