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OpenTrials
Enrolling by Invitation

NCT Number: NCT06786728

Decongestion Guided By VExUS Score Or Lung Ultrasound For Renal Recovery In Patients With Cardiorenal Syndrome Type -1

the goal of this observational study is to evaluate the role of VEXUS score and lung ultrasound to guide decongestive therapy in patients with cardiorenal syndrome type -1. the main question it aims to answer is: Can the VEXUS score and lung ultrasound guide the efffect of decongestive therapy on KFR and decongestion metrics in patients with CRS-1 compared to standard assesment ?

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Key information

Conditions

Cardiorenal Syndrome Type 1

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Asmaa Shahat Mohamedy Behairy

Cairo, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • • Patients of both genders aged 18-65 years old.
  • Patients with CRS1 criteria (worsening of renal function due to acute heart failure manifested by : ( Dyspnea , orthopnea ,hypoxia , congested neck veins , oliguria and congestion in imaging.)
  • Patients with Modified lung ultrasound score(LUSS) more than 15.

Exclusion criteria

  • • Refusal to participate.
  • Patients with renal transplantation.
  • Unknowing baseline creatinine.
  • Patients with a life-threatening indication of RRT (defined as intractable hyperkalemia, acidosis, uremic symptoms) at enrollment,
  • RRT before recruitment,
  • known prehospitalization advanced chronic kidney disease (defined by an estimated GFR <30 mL/min/1.73 m2 or chronic RRT),
  • use of extracorporeal membrane oxygenation (ECMO),
  • diagnosis of hepatic cirrhosis or other condition with portal hypertension
  • Or postrenal causes of AKI

Treatment and study plan

frusemide

Drug

in this group we use vexus score to asses decongestion in comparison to lung ultrasound in other group

Primary outcomes

  1. assesment of KFR using the KDIGO AKI staging improvement

    Time frame: 1 week

    stage1:serum creatinine increase 1,5 - 2 folds serum creatinine increase 2 - 3 folds serum creatinine increase more than 3 folds

Secondary outcomes

  1. VEXUS score

    Time frame: 48 hours

    grade 1 : no congestion grade 2:mild congestion grade 3 moderate congestion grade 4 : severe congestion

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Official study title

Evaluation of Decongestion Guided By VExUS Score Or Lung Ultrasound For Renal Recovery In Patients With Cardiorenal Syndrome Type-1 : a Randomized Controlled Trial

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Jan 22, 2025
Registry last updated
Jan 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.