Decompression Intervention of Variceal Rebleeding Trial (DIVERT)

The Decompression Intervention of Variceal Rebleeding Trial (DIVERT) is a multi-center prospective randomized clinical trial comparing the radiologic procedure of transjugular intrahepatic portal-systemic shunt (TIPS) with the surgical procedure of distal splenorenal shunt (DSRS) for variceal bleeding in patients with Child's Class A and B cirrhosis.

This is recognized nationally and internationally as the study that will answer the question as to which of these is the best treatment for decompression of varices in patients who have failed endoscopic and pharmacologic therapy.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Esophageal and Gastric Varices Cardiovascular Diseases Digestive System Diseases Esophageal Diseases Fibrosis Gastrointestinal Diseases Hypertension, Portal Liver Cirrhosis Liver Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Varicose Veins Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

University of Miami School of Medicine, Miami, Florida, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Variceal bleeding secondary to cirrhosis and portal hypertension
Child's Class A or B cirrhosis of any etiology
Patients who have failed endoscopic therapy (sclerotherapy or banding) of varices; or patients who are not candidates for endoscopic therapy

Exclusion criteria

Prior shunt procedure
Portal vein thrombosis
Polycystic liver disease
Intractable ascites
Prior organ transplant
Any medical intractable disease

Treatment and study plan

Transjugular intrahepatic portosystemic shunt (TIPS)

Procedure

Distal Splenorenal Shunt

Procedure

Sponsors and collaborators

Lead sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Nih

Registry information

Official study title

Decompression Intervention of Variceal Rebleeding Trial

Important dates

Study start: 1996
Study completion: 2003
First posted: Aug 9, 2000
Registry last updated: Jan 13, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed