Decode the Environment Variation of Targeted Aldosterone Inducer and siLencer

Primary Objective1: to identify CYP450 Family 11 Subfamily B and Aldosterone in hypertension patients following; By structure ● Evidence confirms Epigenetic profile of CYP450 Family 11 Subfamily B, Aldosterone, Signal in hypertension patients, both random and treated from any DNA sequencing method Protein synthesis evidence of aldosterone protein induces hypertension from Western blot or LC-MS By function Metabolomic profile: the substrate or product refers to aldosterone interaction causing end-organ cell line dysfunction or impaired structure.

Inhibitory signaling profiling of hypertension patients compared to non-hypertension patients, which negatively feedback to CYP450 Family 11 Subfamily B or Aldosterone

Secondary Objective 2:

Sub-group analysis effect measurement following;

• Proposed mechanisms, biological markers, or pathways that contribute to failure to regulate aldosteronemia
• Treatment-related permanent normotensive post-hyperaldosteronemia. Primary Objective 2: Identify possible intracellular signal inhibit aldosterone action
• Analyze possible mechanisms of signal that are silent aldosterone-MR activity
• Differentiation of free aldosterone and attached aldosterone

Secondary Objective 2:

● Sensitivity and specificity of outcomes of hypertension patients who underwent estimate substrate associated aldosterone circulation Plasma CYP450 Family 11 Subfamily B Urine CYP450 Family 11 Subfamily B Plasma Aldosterone (active form) Plasma Aldosterone (metabolite form) Urine Aldosterone Axin-CK1-GSK3-APC-Beta-catenin complex

Inclusion criteria

• Human birth in all sex chromosomes; evidence of systemic arterial hypertension, both treated and untreated.
• Evidence of living with owned systemic/arterial hypertension by one of the following;
• Quantitative: Blood pressure number higher than the normal range by each protocol in mmHg unit in any arm of study.
• Qualitative: Clarify whether both retrospective, observational, or intervention study of blood pressure, and clearly clarify the number of hypertension participants in the article.

Exclusion criteria

• Under 18 years old
• Specimens of studies not from humans or human specimens but not from an actual living hypertension patient, such as cell culture, in vitro synthesis from laboratory synthesis
• No evidence of hypertension in the main study
• Study of imaging confirms adrenal tumor in all types of histopathology results.