University Hospital Zurich
Zurich, Canton of Zurich, 8091, Switzerland
NCT Number: NCT03692962
The aim of this project is to investigate whether enhancing sleep intensity locally in the prefrontal cortex (PFC) can counteract a deterioration of cognitive control and therefore the previously described increase in risk seeking during chronic sleep restriction. To this end, a controlled, counter-balanced study, consisting of two weeks of sleep restriction will be performed. During one of the sleep restriction weeks, sleep intensity in the PFC will be non-invasively enhanced by acoustic stimulation of slow waves during sleep.
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Notify Me18 year–30 year
Male
Interventional
Not applicable
Zurich, Canton of Zurich, 8091, Switzerland
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
Time in bed will be restricted to 5 hours per night for 7 nights.
Brief tones will be presented time-locked to ongoing slow waves during deep sleep.
Time frame: comparison of change from baseline after 7 nights of sleep restriction with acoustic stimulation to change from baseline after 7 nights of sleep restriction without acoustic stimulation
risk-preference (i.e. risk premium assessed with the risk Task as described in Maric et al. 2017 Ann Neurol) after chronic sleep restriction with and without acoustic Stimulation will be quantified by the risk-premium derived from the choices made in the risk-task as described in Maric et al. 2017 Ann Neurol.
Time frame: assessed during first and last sleep restriction nights in comparison to baseline values
Slow wave activity (SWA) assessed by hd-EEG with 128 electrodes
Time frame: before to after 7 nights of sleep restriction with and without acoustic stimulation
Glutamate and gamma-aminobutyric acid (GABA) concentration in the right prefrontal Cortex assessed by magnetic resonance (MR) spectroscopy
Time frame: before to after 7 nights of sleep restriction with and without acoustic stimulation
Performance impairments in the psychomotor-vigilance task
Time frame: before to after 7 nights of sleep restriction with and without acoustic stimulation
deception willingness measured by the willingness to deception of outcome in a card game with binary outcome (win and loss)
Time frame: before to after 7 nights of sleep restriction with and without acoustic stimulation
inhibitory control performance measured by the stop-signal-task.
Time frame: before to after 7 nights of sleep restriction with and without acoustic stimulation
overconfidence measured by an incentivised procedure that elicits the certainity equivalent of a bet based on Performance in a quiz (cf. Murad et al. 2016 J Risk Uncertain)
Time frame: before to after 7 nights of sleep restriction with and without acoustic stimulation
overconfidence measured by an incentivised procedure that elicits the certainity equivalent of a bet based on Performance in a quiz (cf. Murad et al. 2016 J Risk Uncertain)
Time frame: before to after 7 nights of sleep restriction with and without acoustic stimulation
impulsivity as measured by an intertemporal choice Task.
Time frame: before to after 7 nights of sleep restriction with and without acoustic stimulation
Ocular inhibitory control Performance measured by the Anti-Saccade Task.
Time frame: before to after 7 nights of sleep restriction with and without acoustic stimulation
Pupil response (i.e. dilation) during a simple Go/No-Go Task.
Time frame: before to after 7 nights of sleep restriction with and without acoustic stimulation
Excessive daytime sleepiness assessed by the Epworth sleepiness scale and the Stanford Sleepiness Scale.
Christian Baumann
Other
Linking the Change in Decision-making After Sleep Restriction to the Restorative Function of Sleep
Acronym: DM-SR
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