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Completed

NCT Number: NCT05111665

Decentering and Relapse/Recurrence in MBCT for Depression in Adults

Objective: "Decentering" is defined as the ability to observe one's thoughts and feelings as temporary, objective events in the mind, and is increasingly regarded as a candidate mechanism in mindfulness-based interventions. The current study sought to examine the role of decentering, and other related variables, in the efficacy of Mindfulness-based cognitive therapy (MBCT) as compared to two active comparison conditions.

Method: Formerly depressed individuals (N = 227), randomly assigned to MBCT (n = 74), relaxation group therapy (RGT; n = 77) or treatment-as-usual (TAU; n = 76), completed self-report measures of decentering and symptoms of depression at pre-, mid-, and post-treatment, and relapse was assessed at 3, 6, 9, and 12 months, post-treatment.

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Key information

Conditions

Depression Behavior Behavioral Symptoms Depression in Remission Depressive Disorder Depressive Disorder, Major Mental Disorders Mood Disorders

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Mark Lau

Vancouver, British Columbia, V6J 5C6, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • a Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM IV-TR; American Psychiatric Association (APA), diagnosis of major depressive disorder (MDD) without psychotic features, in Full Remission;
  • three or more prior major depressive episodes;
  • age between 18 and 65 years;
  • cognitive reactivity (CR) or mood-activated dysfunctional beliefs score greater than or equal to eight (see assessment procedure below);
  • a score of less than 10 on the Hamilton Rating Scale for Depression (HRSD);
  • minimum of a 10 week period free of psychotropic medication other than stable dosage of antidepressant medication for a minimum of four weeks;
  • fluency in English; An increased cognitive reactivity score of eight points or more and,
  • ability to give informed consent and complete questionnaires unassisted.

Exclusion criteria

  • a diagnosis of bipolar disorder (past or present), schizophreniform disorders, substance abuse or dependence (current or within the past six months), borderline or antisocial personality disorder, or neurocognitive disorders;
  • current psychotherapy or counselling more frequently than twice per month;
  • current practice of meditation more than once per week or yoga more than twice per week;
  • electroconvulsive therapy within the past six months; or
  • self-reported ingestion of alcohol or other psychoactive substances within the past 48 hrs.

Treatment and study plan

Mindfulness-based cognitive therapy (MBCT)

Behavioral

Relaxation Group Therapy (RGT)

Behavioral

Treatment as Usual (TAU)

Behavioral

Primary outcomes

  1. Major depressive disorder (MDD) relapse/recurrence - incidence of

    Time frame: 12- month post-treatment follow-up

    Number of participants meeting criteria for relapse/recurrence of MDD during follow-up

  2. Change in major depressive disorder (MDD) relapse/recurrence - time to relapse/recurrence

    Time frame: 3-, 6-, 9-, and 12- month post-treatment follow-up

    Change in relapse/recurrence of MDD (i.e., survival) across follow-up

Secondary outcomes

  1. Change in Beck Depression Inventory - Second Edition total scores

    Time frame: Pre-, mid- (i.e., at week 4 of MBCT), and post-treatment (i.e., after 8 weeks of MBCT)

    Change in symptoms of depression across MBCT treatment

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Registry information

Official study title

The Association Between Decentering and Reductions in Relapse/Recurrence in Mindfulness-Based Cognitive Therapy for Depression in Adults: A Randomized Controlled Trial

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Nov 8, 2021
Registry last updated
Nov 8, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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