Debate on Progesterone Elevation on the Day of Triggering

The association between serum progesterone (P) levels, measured on the day of ovulation trigger, and the outcome of in vitro fertilization cycles, has been one of the major controversies in the field of ovarian stimulation endocrinology.

This is a single-center retrospective cohort study. Study duration period is from January 2012 to December 2016.

All fresh embryo transfer (ET) both at cleavage stage and blastocyst stage, performed in Humanitas Fertility Center during the study period, were included.

Completed

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Key information

Conditions

Progesterone ART Embryo Transfer Female Infertility Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Infertility Infertility, Female Urogenital Diseases

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

Paolo Emanuele Levi Setti

Rozzano, MI, 20089, Italy

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

All fresh embryo transfers both at cleavage stage (Day 2 and Day3) and blastocyst stage (Day 5)
Thawed embryo transfer deriving from supernumerary embryos cycles, by P increase, by OHSS, by other reasons (i.e inadequate endometrium, medical complications, etc)

Exclusion criteria

thawed embryo transfers deriving from PGTA.

Treatment and study plan

Embryo transfer

Other

Step of the assisted reproduction in which embryos are placed into the uterus in order to obtain a pregnancy

Primary outcomes

Impact of PE on CPR and LBR

Time frame: January 2012-December 2016

To evaluate the impact of premature high serum P levels on the outcome of fresh embryo transfer cycles in terms of Clinical Pregnancy Rates (CPR) and Live Birth Rates (LBR).

Secondary outcomes

Blastocyst embryo transfers' outcomes in PE

Time frame: January 2012-December 2016

Furthermore, the present study retrospectively investigates whether the transfer of blastocysts on day 5 post-fertilization (D5-ET) may improve the CPR and the LBR in patients with P rise.

Sponsors and collaborators

Lead sponsor

Istituto Clinico Humanitas

Other

Registry information

Official study title

The Neverending Debate on Progesterone Elevation: Possible Solutions

Acronym: PE

Important dates

Study start: 2012
Primary completion: 2016
Study completion: 2019
First posted: Feb 5, 2020
Registry last updated: Feb 5, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed