Dapagliflozin Effect on Glucose Variability in Patients Post Bariatric Surgery

Dapagliflozin is a highly selective sodium-glucose transporter 2 (SGLT2) inhibitor, an approved drug for the treatment of type 2 diabetes. It leads to urinary glucose excretion and a reduction of weight. This results in a reduction of both fasting and postprandial glucose levels. This is reported that the treatment of type 2 diabetes with dapagliflozin carries a low risk of hypoglycaemia and have a beneficial effect on weight and blood pressure.

This study hypothesized that bariatric surgery is effective for weight loss. But some patients experience large changes in the blood glucose after meals that lead to hyper and hypoglycaemia and weight regain. This study propose that the use of SGLT-2 inhibitors, which lower glucose and body weight by promoting its renal excretion, will reduce glucose variability in patients after bariatric surgery.

Inclusion criteria

• People diagnosed with type 2 diabetes prior to bariatric surgery.
• People did not have diabetes prior to bariatric surgery.
• Willing to participate in this study.

Exclusion criteria

• Type 1 diabetes
• Secondary diabetes
• History of ketoacidosis
• History of pancreatitis and pancreatectomy.
• History of primary renal glycosuria or hereditary glucose-galactose malabsorption.
• Active diabetes complications, nephropathy (dipstick positive proteinuria, or reduced eGFR (<60 ml/min), proliferative retinopathy.
• Clinically significant abnormal liver function test.
• Pregnant ladies, or intending pregnancy or breastfeeding.
• Patients using insulin therapy or a sulfonylurea.
• Uncontrolled hypertension.
• Uncontrolled thyroid disease.
• Any history of serious hypertension reaction to the dapagliflozin or SGLT-2 inhibitor.
• History of malignancy within 5-year of screening.
• Presence of any other medical condition that would in the opinion of the investigator, preclude safe participation in the study.
• HbA1c >10.5
• Unable to sign the consent form.