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OpenTrials
Completed

NCT Number: NCT04332952

Damage and Renal Clearance of Glycocalyx in Cardiac Surgery

The glycocalyx is a component of the vascular endothelium that currently plays a relevant role in the modified Starling theory.

The manipulation of the heart during cardiac surgery stimulates the release of the natriuretic atrial peptide, which causes endothelial wear in patients undergoing extracorporeal circulation. Dilation of the atrium produces natriuretic atrial peptide, which reduces plasma volume by increasing renal excretion and vascular permeability. The atrial peptide degrades the surface of the coronary endothelium, causing loss of the side cam protein nucleus. This study investigates the relationship between clamping time in cardiac surgery and the clearance of endothelial inflammation markers.

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Key information

Conditions

Glycocalyx Cardio-Renal Syndrome Cardiovascular Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Heart Diseases Heart Failure Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital Beneficencia Española de Puebla

Puebla City, 72090, Mexico

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Over 18 years of age
  • Patients who underwent cardiac surgery for a single valve change or replacement

Exclusion criteria

  • Stage 3 renal failure patients
  • Patients with a previous diagnosis of hematological malignancy
  • Patients undergoing pulmonary valve change surgery.
  • Patients undergoing Bentall and Bono surgery.
  • Patients Undergoing Coronary Artery Bypass Surgery

Treatment and study plan

Primary outcomes

  1. Extracorporeal circulation time

    Time frame: 2 hours

    Duration of Extracorporeal Circulation in minutes

  2. Aortic clamping time

    Time frame: 2 hours

    Duration of aortic clamping time in minutes

  3. Hyaluronic acid levels in blood before surgery

    Time frame: 30 minutes

    Quantity of hyaluronic acid in blood before surgery

  4. Hyaluronic acid levels in blood after surgery

    Time frame: 30 minutes

    Quantity of hyaluronic acid in blood after surgery

  5. Hyaluronic acid levels in urine before surgery

    Time frame: 30 minutes

    Quantity of hyaluronic acid in urine before surgery

  6. Hyaluronic acid levels in urine after surgery

    Time frame: 30 minutes

    Quantity of hyaluronic acid in urine before surgery

  7. Sydecan -1 levels in blood before surgery

    Time frame: 30 minutes

    Quantity of Sydecan -1 in blood before surgery

  8. Sydecan -1 levels in blood after surgery

    Time frame: 30 minutes

    Quantity of Sydecan -1 in blood after surgery

  9. Sydecan -1 levels in urine before surgery

    Time frame: 30 minutes

    Quantity of Sydecan -1 in urine before surgery

  10. Sydecan -1 levels in urine after surgery

    Time frame: 30 minutes

    Quantity of Sydecan -1 in urine after surgery

Sponsors and collaborators

Lead sponsor

Miguel Ayala León

Network

Collaborators

  • Instituto Nacional de Cardiologia Ignacio Chavez

Registry information

Acronym: GlycoCarSur

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Apr 3, 2020
Registry last updated
Apr 9, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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