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OpenTrials
Completed

NCT Number: NCT02245035

Dairy Intake and Brain Health in Aging

The purpose of this study is to learn if dairy food consumption may help brain health in aging by protecting nerve cells from oxidative damage.

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Key information

Age range

60 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Kansas Medical Center

Kansas City, Kansas, 66160, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Males and females between 60-85 years of age.
  • Good general health with no concomitant diseases, which would be expected to interfere with the study
  • BMI range 20-35 kg/m2

Exclusion criteria

  • Presence of any central neurological disease with the potential to impair cognition(e.g., brain tumor, stroke, epilepsy, motor neuron disease, multiple sclerosis, Alzheimer disease, Parkinson's disease) or prior major head trauma with loss of consciousness
  • Presence of an active unstable and life-threatening systemic illness (e.g., cancer)
  • Presence of major psychiatric disorder within the past 3 years including depression, anxiety, and alcohol (over 3 drinks per day or total of 18 per week) or drug abuse (DSM-IV criteria; Geriatric Depression Score>6)
  • Presence of diabetes mellitus (defined as a clinical diagnosis or use of an anti-diabetic agent) and metabolic syndrome
  • Use of psychoactive and investigational medications
  • Subjects with MRI contraindications such as pacemaker, aneurysm clips, artificial heart valves, metal fragments, foreign objects or claustrophobia. All subjects subjects will receive a structural MRI as part of this study. Individuals with evidence of infection, infarction, neoplasm or other lesions will be excluded. Individuals found to have abnormalities in their structural MRI will be referred to their primary physician for further evaluation and management.
  • Pregnancy
  • Special diet regimens such as lactose free or vegan

Treatment and study plan

Primary outcomes

  1. Cerebral glutathione (GSH) levels measured by magnetic resonance spectroscopy (MRS)

    Time frame: Baseline

  2. Dietary dairy food intake measured using 7-day diet recording

    Time frame: 1 week, prior to MRS scan

Sponsors and collaborators

Lead sponsor

University of Kansas Medical Center

Other

Collaborators

  • National Dairy Council

Registry information

Important dates

Study start
2011
Primary completion
2013
Study completion
2014
First posted
Sep 19, 2014
Registry last updated
Mar 21, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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