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Completed

NCT Number: NCT05813769

Dairy and Plant Amino Acid Uptake. An Explorative Study

To optimize the environmental sustainability, a protein transition to more plant-based protein sources is required. However, the protein quality of plant-based sources is lower than that of the dairy proteins casein and whey, which contain high levels of essential amino acids. The amino acid absorption characteristics of many plant-based proteins are unknown.

The present study aims to estimate differences in postprandial plasma total essential amino acids (TEAA) profiles after protein consumption of different protein sources in blood of healthy participants. This explorative study has a randomized, cross-over, double-blind, controlled design.

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Key information

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Wageningen Food & Biobased Research, Food, Health & Consumer Research

Wageningen, Gelderland, 6708 WG, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Apparently healthy men and women;
  • Age ≥18 and ≤40 years;
  • Body mass index (BMI) ≥18.5 and ≤30 kg/m2 ;
  • Having veins suitable for blood sampling via a catheter (judged by study nurse/ medical doctor).

Exclusion criteria

  • Any self-reported metabolic, gastrointestinal, inflammatory or chronic disease (such as anemia, diabetes, hepatitis, cardiovascular disease);
  • Having a history of medical or surgical events that may significantly affect the study outcome;
  • Anaemia (Haemoglobin (Hb) values <7.5 mmol/L for women and <8.5 mmol/L for men), as assessed by finger prick blood during screening visit;
  • Having a food or protein allergy
  • Use of glucose lowering drugs, insulin;
  • Use of medication that may impact gastric emptying (e.g. gastric acid inhibitors or laxatives);
  • Use of antibiotic treatment less than 1 month before start of the study and during the study;
  • Use of anti-depressives as a treatment for depression;
  • Use of protein supplements (must be stopped 1 week before the first test day);
  • Reported weight loss or weight gain of > 3 kg in the month prior to pre-study screening, or intention to lose weight during the study period;
  • Reporting to follow or having planned a slimming or medically prescribed diet.
  • Not willing to keep a stable lifestyle during the study period;
  • Recent blood donation (<1 month prior to test day 1 of the study) or not willing to stop donation during and 1 month after the study;

Treatment and study plan

Dairy protein

Dietary Supplement

During each visit, research subjects will receive the product dissolved in water, representing a 20g protein load.

Plant protein

Dietary Supplement

During each visit, research subjects will receive the product dissolved in water, representing a 20g protein load.

Primary outcomes

  1. Postprandial blood TEAA profiles

    Time frame: Frome baseline up to 5 hours postprandial

    Postprandial plasma total essential amino acids (TEAA) profiles after protein consumption, determined by appearance in blood.

Sponsors and collaborators

Lead sponsor

FrieslandCampina

Industry

Collaborators

  • Wageningen University and Research

Registry information

Acronym: DaPa

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Apr 14, 2023
Registry last updated
Jun 26, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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