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Enrolling by Invitation

NCT Number: NCT06958640

Da Qing Offspring Study

This is an observational study tracking families and offspring of three cohorts from the 1986 Da Qing study: newly diagnosed diabetes, impaired glucose tolerance, and normoglycemia groups. Based on the original participants, the study will further include their spouses, first to third-generation offspring, and spouses of the offspring. General demographic information will be collected, and anthropometric measurements will be refined. A structured questionnaire will be used to gather disease history, family history of diabetes, and related information. Comprehensive diabetes-related laboratory screening and complication assessments will be conducted. A standardized biobank will be established, including blood and urine samples from the Da Qing Offspring Study, to support future research on epigenetics, metabolomics, and other mechanisms.

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Key information

Conditions

Diabetes Mellitus Cancer Cardiovascular Diseases Cardiovascular Diseases (CVD) Comorbidity Endocrine System Diseases Glucose Intolerance Glucose Metabolism Disorders Hyperglycemia Impaired Glucose Tolerance (Prediabetes) Inter- and Transgenerational Inheritance Metabolic Diseases Neoplasms Nutritional and Metabolic Diseases Offspring, Adult Prediabetic State Prevention

Sex eligibility

All sexes

Study type

Observational

Primary location

China-Japan Friendship hospital

Beijing, Beijing Municipality, 100029, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Spouses of the original Daqing diabetes Prevention Research Population (IGT), offspring 1 to 3 generations, and offspring spouses were included in the study, without special restrictions on subjects' gender, age, basic disease status, etc。
  • Conduct a death agent investigation for some deceased members.

Exclusion criteria

▪People who are unwilling to participate in this study

Treatment and study plan

Lifestyle interventions

Behavioral

Dietary intervention: 30kcal energy intake per kilogram of body weight per day, increase vegetable intake, control sugar and alcohol intake, encourage overweight and obese people to lose weight, lose 0.5-1kg per month until the weight reaches the target.

Exercise intervention: Appropriate physical activity in spare time, 30-40 minutes per day, 5 times a week.

Primary outcomes

  1. Cumulative incidence rate of diabetes

    Time frame: Through study completion, an average of about 1.5 years

    This study statistically analyzed the cumulative incidence rate of diabetes at the end of the study through interview, medical record review, physical examination

Secondary outcomes

  1. weight

    Time frame: Through study completion, an average of about 1.5 years

    The subject's weight is recorded and the results are reported in kilograms.

  2. waist circumference

    Time frame: Through study completion, an average of about 1.5 years

    The subjects' waist circumference was recorded and the waist circumference results were reported in centimeters.

  3. Height

    Time frame: Through study completion, an average of about 1.5 years

    The subject's height was recorded, and the results were recorded in centimeters.

  4. Exercise frequency and intensity

    Time frame: Through study completion, an average of about 1.5 years

    The subjects' daily exercise frequency and intensity were recorded.

  5. Coronary heart disease incidence

    Time frame: Through study completion, an average of about 1.5 years

    This study statistically analyzed the incidence of coronary heart disease at the end of the study through interview, medical record review, physical examination

  6. all-cause deaths

    Time frame: Through study completion, an average of about 1.5 years

    This study counted all-cause deaths at the end of the study through death certificate, medical record review, family interview

  7. incidence of diabetic peripheral neuropathy

    Time frame: Through study completion, an average of about 1.5 years

    This study statistically analyzed the incidence of diabetic peripheral neuropathy at the end of the study through interview, medical record review, physical examination

  8. other cause mortality

    Time frame: Through study completion, an average of about 1.5 years

    This study statistically analyzed other cause mortality at the end of the study through death record, medical record review, family interview

  9. cardiovascular mortality rate

    Time frame: Through study completion, an average of about 1.5 years

    This study statistically analyzed the cardiovascular mortality rate at the end of the study through death certificate, medical record review, family interview

  10. incidence of blindness

    Time frame: Through study completion, an average of about 1.5 years

    This study statistically analyzed the incidence of blindness at the end of the study through interview, medical record review, physical examination

  11. Diabetic retinopathy incidence

    Time frame: Through study completion, an average of about 1.5 years

    This study statistically analyzed the incidence of diabetic retinopathy at the end of the study through interview, medical record review, physical examination

  12. Diabetic nephropathy incidence

    Time frame: Through study completion, an average of about 1.5 years

    This study statistically analyzed the incidence of diabetic nephropathy at the end of the study through interview, medical record review, physical examination

  13. Peripheral vascular disease incidence

    Time frame: Through study completion, an average of about 1.5 years

    This study statistically analyzed the incidence of peripheral vascular disease at the end of the study through interview, medical record review, physical examination

  14. Heart failure incidence

    Time frame: Through study completion, an average of about 1.5 years

    This study statistically analyzed the incidence of heart failure at the end of the study through interview, medical record review, physical examination

  15. Stroke incidence

    Time frame: Through study completion, an average of about 1.5 years

    This study statistically analyzed the incidence of stroke at the end of the study through interview, medical record review, physical examination

  16. dietary habits

    Time frame: Through study completion, an average of about 1.5 years

    The subjects' eating habits and dietary preferences were assessed through patient interviews.

  17. health-related quality of life

    Time frame: Through study completion, an average of about 1.5 years

    The EuroQol questionnaire or health status questionnaire was administered through patient interviews to assess the subjects' health-related quality of life.

  18. blood pressure

    Time frame: Through study completion, an average of about 1.5 years

    During the visit, the subjects' systolic and diastolic blood pressures were measured at rest by physical examination. The measurements were performed twice and the average was taken.

  19. blood sugar

    Time frame: Through study completion, an average of about 1.5 years

    Blood samples were collected from the subjects at 1 hour and 2 hours after the steamed bread meal when they were fasting. The blood samples were used to test blood sugar levels and blood lipids, including total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.

  20. blood lipid

    Time frame: Through study completion, an average of about 1.5 years

    Venous blood was collected from the subjects in a fasting state. The blood samples were used to test blood lipid status, including total cholesterol, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.

  21. skin AGE

    Time frame: Through study completion, an average of about 1.5 years

    The skin AGE of the subjects was measured by physical examination. After cleaning the inner skin of the forearm, the AGE Reader probe was gently placed on the skin surface, the excitation light was emitted and the fluorescence intensity was recorded. The results were repeated 3 times and the average value was taken.

  22. Tidal Volume

    Time frame: Through study completion, an average of about 1.5 years

    The subjects were assessed for Tidal Volume, which reflects the ventilation efficiency in the basic breathing state. Tidal Volume is measured in liters.

  23. Functional Residual Capacity

    Time frame: Through study completion, an average of about 1.5 years

    Subjects were assessed for Functional Residual Capacity, which reflects lung capacity. Functional Residual Capacity is measured in liters.

  24. Forced Vital Capacity

    Time frame: Through study completion, an average of about 1.5 years

    The subjects were assessed for Forced Vital Capacity, which reflects the overall ventilation capacity of the lungs. Forced Vital Capacity is measured in liters.

  25. Forced Expiratory Volume in 1 second

    Time frame: Through study completion, an average of about 1.5 years

    The subjects were assessed for Forced Expiratory Volume in 1 second, which reflects respiratory reserve capacity. Forced Expiratory Volume in 1 second is measured in liters.

Sponsors and collaborators

Lead sponsor

China-Japan Friendship Hospital

Other

Collaborators

  • Daqing Oil Field Hospital

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
May 6, 2025
Registry last updated
May 6, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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