D Vitamin and Alveolar Macrophages in Idiopathic Pulmonal Fibrosis

The goal of this observational study is to gain deeper insights into human macrophages and vitamin D, and their interplay, within Idiopathic Pulmonary Fibrosis (IPF).

The overall questions, it aims to answer, are the following:

Do IPF patients suffer from systemic and local (pulmonary) insufficient levels of vitamin D? Do IPF patients suffer from pro-fibrotic and pro-inflammatory pulmonary macrophages?

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Key information

Conditions

Idiopathic Pulmonary Fibrosis (IPF) Idiopathic Pulmonary Fibrosis Lung Diseases Lung Diseases, Interstitial Pulmonary Fibrosis Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Aarhus University Hospital, Denmark

Aarhus N, 8200, Denmark

Location status: Recruiting

Location contact

Anne J Nielsen, PhD Student

CONTACT

[email protected]

+45 29611543

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

A clinical diagnosis of IPF, non-IPF ILD or lung cancer
A signed informed consent

Exclusion criteria

Do not speak Danish/Do not understand Danish

Treatment and study plan

Primary outcomes

Vitamin D status

Time frame: At enrollment

Significant change in vitamin D levels in systemic (blood) and local (pulmonary) metabolism.
Pulmonary macrophages

Time frame: At enrollment

Significant change in alveolar macrophage phenotype

Secondary outcomes

Biomarker levels in blood and BAL samples

Time frame: At enrollment

Significant change in levels of macrophage and inflammatory/fibrotic biomarkers

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2026
Study completion: 2026
First posted: Apr 3, 2025
Registry last updated: Apr 3, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting