CytoSorb in Patients With Liver Failure

Hemoadsorption has been demonstrated to improve liver functional tests in patients with liver failure. The present study investigates the effects of three consecutive sessions of hemoadsorption, performed in accordance to the local protocol for treating patients with acute liver failure, on liver functional tests, severity scores and 30-days mortality. Paraclinical results and severity scores were obtained before and after the three consecutive sessions.

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Key information

Conditions

Liver Dysfunction Digestive System Diseases Liver Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fundeni Clinical Institute

Bucharest, 022328, Romania

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients with acute liver failure or acute on chronic liver failure who require hemoadsorption in accordance with local guidelines

Exclusion criteria

unsigned informed consent
duration of therapy under 12 hours
death before the three consecutive sessions

Treatment and study plan

hemoadsorption

Procedure

three consecutive sessions of hemoadsorption in patients with liver failure

Primary outcomes

30 days mortality

Time frame: 30 days

30 days mortality

Sponsors and collaborators

Lead sponsor

Institutul Clinic Fundeni

Other

Registry information

Official study title

Effects of Renal Replacement Therapy With Hemoadsoption in Patients With Liver Failure

Important dates

Study start: 2016
Primary completion: 2021
Study completion: 2021
First posted: Aug 13, 2020
Registry last updated: Sep 5, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed