Cyclic On-off Switching of Pulmonary Blood Flow in Moderate to Severe ARDS

Although the theoretical model of "cyclic on-off switching of pulmonary blood flow" provides a crucial perspective for understanding VILI, its clinical validation and real-time intervention face significant obstacles. The fundamental reason lies in the lack of pulmonary microcirculation monitoring technology capable of bedside, non-invasive, continuous operation with sufficient spatiotemporal resolution. Nowadays, a novel 3D-EIT can perform real-time and non-invasive assessment of the distribution of pulmonary blood flow. However, if 3D-EIT can help to identify "cyclic on-off switching of pulmonary blood flow" is still unclear.

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Key information

Conditions

ARDS (Acute Respiratory Distress Syndrome) Acute Lung Injury Electrical Impedance Tomography (EIT) Lung Diseases Lung Injury Pulmonary Perfusion Respiratory Tract Diseases

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Zhongda Hospital, School of Medicine, Southeast University

Nanjing, Jiangsu, 210009, China

Location contact

yuan xueyan, MD

CONTACT

[email protected]

+86 83262550

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients with mechanical ventilation
diagnosis of moderate to severe ARDS no more than 72 hours

Exclusion criteria

Chronic respiratory diseases that required long-term oxygen therapy, such as pulmonary fibrosis or chronical obstructive pulmonary disease
Contraindications to EIT (e.g., active implantable device, chest malformation, unstable spinal injuries or fractures, and open chest wounds)
Undrained pneumothorax or pneumomediastinum,
Hemodynamic instability
Pregnancy
Refusal by family or the attending physician to participate in the study.

Treatment and study plan

Primary outcomes

The percent of "Cyclic On-Off Switching"

Time frame: 15min

"Cyclic On-Off Switching" was assessed by 3D-EIT

Study contacts

Contact information is provided by the study sponsor or research team.

ling liu Liu, PhD

CONTACT

[email protected]

+86 83262550

Sponsors and collaborators

Lead sponsor

Southeast University, China

Other

Registry information

Official study title

Cyclic On-off Switching of Pulmonary Blood Flow in Moderate to Severe ARDS Patients With Mechanical Ventilation

Important dates

Study start: 2026
Primary completion: 2026
Study completion: 2026
First posted: Jan 8, 2026
Registry last updated: Jan 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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