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NCT Number: NCT07359300

Cyanoacrylate Versus Sutures for Free Gingival Graft Stabilization

This randomized controlled clinical trial evaluated the effectiveness of butyl-cyanoacrylate tissue adhesive compared with conventional sutures for stabilization of free gingival grafts. Twenty-four patients with insufficient keratinized tissue were randomly assigned to either cyanoacrylate or suture stabilization following free gingival graft surgery. Clinical parameters, graft dimensional changes, patient-reported postoperative discomfort, and operative time were assessed over a 6-month follow-up period.

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Key information

Conditions

Insufficient Keratinized Tissue Gingival Diseases Gingival Recession Mouth Diseases Mucogingival Defects Periodontal Atrophy Periodontal Diseases Stomatognathic Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Yeditepe University

Istanbul, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older
  • Presence of ≤1 mm of keratinized tissue and/or Miller Class I gingival recession ≤2 mm affecting one to four mandibular anterior teeth
  • Vital teeth in the surgical area
  • Good oral hygiene following initial periodontal therapy (full-mouth plaque score and full-mouth bleeding score ≤20%)
  • Ability to understand the study procedures and provide written informed consent

Exclusion criteria

  • Current smokers
  • Pregnancy or lactation
  • Use of systemic antibiotics within the previous 6 months
  • History of periodontal surgery in the study area
  • Ongoing orthodontic treatment
  • Systemic conditions that could affect periodontal healing

Treatment and study plan

Free Gingival Graft Stabilization With Butyl-Cyanoacrylate

Procedure

Stabilization of free gingival grafts using butyl-cyanoacrylate tissue adhesive following standard free gingival graft surgery.

Free Gingival Graft Stabilization With Sutures

Procedure

Stabilization of free gingival grafts using non-resorbable polypropylene sutures following standard free gingival graft surgery.

Primary outcomes

  1. Change in Keratinized Tissue Width

    Time frame: Baseline and 6 months postoperatively

    Change in keratinized tissue width measured at the surgical sites using a periodontal probe.

Secondary outcomes

  1. Total Graft Surface Area (TGSA)

    Time frame: Baseline, 1 month, 3 months, and 6 months postoperatively

    Changes in total graft surface area assessed using standardized clinical photographs and digital measurements.

  2. Vertical Graft Height (VGH)

    Time frame: Baseline, 1 month, 3 months, and 6 months postoperatively

    Changes in vertical graft height assessed using standardized clinical photographs and digital measurements.

  3. Probing Depth (PD)

    Time frame: Baseline and 6 months postoperatively

    Changes in probing depth measured at the surgical sites using a periodontal probe.

  4. Vertical Recession (VR)

    Time frame: Baseline and 6 months postoperatively

    Changes in vertical gingival recession measured at the surgical sites using a periodontal probe.

  5. Full-Mouth Plaque Score (FMPS)

    Time frame: Baseline and 6 months postoperatively

    Changes in full-mouth plaque score assessed to evaluate oral hygiene status.

  6. Full-Mouth Bleeding Score (FMBS)

    Time frame: Baseline and 6 months postoperatively

    Changes in full-mouth bleeding score assessed to evaluate periodontal inflammation.

  7. Postoperative Pain and Discomfort

    Time frame: Day 0 to Day 6 postoperatively

    Patient-reported postoperative pain and discomfort assessed using a visual analogue scale (VAS).

  8. Operative Time

    Time frame: During the surgical procedure

    Duration of the surgical procedure measured from the initial incision to completion of graft stabilization.

Sponsors and collaborators

Lead sponsor

Yeditepe University

Other

Registry information

Official study title

A Randomized Controlled Clinical Trial Comparing Cyanoacrylate and Sutures for Free Gingival Graft Stabilization

Important dates

Study start
2019
Primary completion
2021
Study completion
2021
First posted
Jan 22, 2026
Registry last updated
Jan 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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