CXCL9 and EASIX for Prediction of Acute Graft Versus Host Disease

The prediction of severe acute GVHD before it occurs is of high importance for ensuing clinical decisions and overall success of allogeneic SCT. The key immunologic signatures associated with clinical outcomes after different graft versus host disease prophylaxis methods or peripheral blood stem cell transplant are largely unknown.

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Key information

Conditions

GVHD,Acute

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Henry Ford Health System

Detroit, Michigan, 48202, United States

Location status: Recruiting

Location contact

shatha farhan

CONTACT

[email protected]

313-916-5002

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients >18 year old admitted for allo SCT PB for malignant disease.

Treatment and study plan

Blood sample

Diagnostic Test

blood sample to check CXCL9 and EASIX at day 28 post stem cell transplant

Primary outcomes

predictors of acute GVHD

Time frame: CXCL9 combined with EASIX calculated at day 28 +/- 2 post SCT can be used as predictors of acute GVHD by day 100.

CXCL9 combined with EASIX can be used as predictors of acute GVHD

Study contacts

Contact information is provided by the study sponsor or research team.

shatha farhan, MD

CONTACT

[email protected]

3137133910

Sponsors and collaborators

Lead sponsor

Henry Ford Health System

Other

Registry information

Official study title

CXC-chemokine Ligand 9 (CXCL9) and Endothelial Activation and Stress Index (EASIX) for Prediction of Acute Graft Versus Host Disease

Important dates

Study start: 2023
Primary completion: 2027
Study completion: 2027
First posted: Feb 8, 2023
Registry last updated: May 1, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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