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NCT Number: NCT05695222

Cutaneous Squamous Cell Carcinoma Staging Study

Cutaneous squamous cell carcinoma (CSCC) is the second most common form of skin cancer, and one of the most common cancers worldwide. The majority of CSCCs are easily removed by surgery and have excellent prognosis. However, a small subset has poor outcomes, including secondary spread in the body (metastasis) and death.

The investigators will look at existing CSCC in people from two UK dermatology centres. The investigators will then evaluate the accuracy of current staging systems in predicting risk of poor outcomes in people. The investigators hope that this project will improve the management of patients with CSCC by validating the predictive power of currently available histological staging classifications for cSCC. In the second stage of the study, The investigators will see whether better prediction tools can be found.

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Key information

Conditions

Cutaneous Squamous Cell Carcinoma

Age range

18 year–120 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Dr Emilia Peleva, London, United Kingdom

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Over 18 years old with diagnosis of CSCC

Exclusion criteria

  • Patients who decline for their data to be used for research purposes

Treatment and study plan

This is not an interventional study

Other

This is not an interventional study

Primary outcomes

  1. Recurrence or metastasis

    Time frame: 4 years

    Proportion of patients developing cutaneous squamous cell carcinoma locoregional recurrence, nodal or distant metastases

Sponsors and collaborators

Lead sponsor

Queen Mary University of London

Other

Registry information

Official study title

Comparison of the Prognostic Capacity of Existing Staging Systems for Cutaneous Squamous Cell Carcinoma

Important dates

Study start
2023
Primary completion
2028
Study completion
2028
First posted
Jan 23, 2023
Registry last updated
Apr 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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