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Completed

NCT Number: NCT01082484

Cutaneous Iontophoresis of Iloprost and Treprostinil in Healthy Volunteers

The purpose of this study is to test whether prostacyclin analogues' cathodal iontophoresis induce a cutaneous vasodilation in healthy volunteers's forearm, without local side effects.

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Key information

Conditions

Healthy

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Unité de Pharmacologie Clinique, Inserm CIC3, CHU Grenoble

Grenoble, 38043, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • healthy volunteers
  • age above 18

Exclusion criteria

  • any chronic disease
  • any drug intake

Treatment and study plan

Treprostinil

Drug

Cutaneous iontophoresis at 20 microA/ 100 microA during 20 min

ILOPROST

Drug

Cutaneous iontophoresis at 20 microA/ 100 microA during 20 min

NaCl 0.9%

Drug

Cutaneous iontophoresis at 20 microA/ 100 microA during 20 min

Primary outcomes

  1. Amplitude of forearm cutaneous vasodilatation assessed using laser Doppler imaging

    Time frame: 24 hours

Secondary outcomes

  1. Local tolerance assessed clinically

    Time frame: Day 0 and after 7 days

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Registry information

Acronym: INFLUX-IT-VS

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Mar 8, 2010
Registry last updated
Oct 6, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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