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NCT Number: NCT03993405

Cut-off Values of Muscle Thickness Ratio for Sarcopenia

The loss of muscle mass is one of the major diagnostic criteria for sarcopenia. Many methods are also used for the definition of sarcopenia. However there is no information about cut-off values in this respect in the literature. Therefore, the aim of this study is to determine the cut-off values of this ratio for confirming the diagnosis of sarcopenia.

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Key information

Conditions

Sarcopenia Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ozden Ozkal

Ankara, 06100, Turkey (Türkiye)

About this study

Decreases in total skeletal muscle mass are accepted to be necessary for confirming the diagnosis of sarcopenia. Many methods are also used for the definition of sarcopenia.

However, ultrasound measurements has a high sensitivity and specify for confirming the diagnosis of sarcopenia. However there is no information about cut-off values in this respect in the literature. Therefore, the aim of this study is to determine the cut-off values of this ratio for confirming the diagnosis of sarcopenia.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • To be a volunteer to participate
  • To be an aged 18-90 years old.

Exclusion criteria

  • Walking with assist device
  • Having a visual deficits
  • Having an undergone orthopedic surgery
  • Having a cardiac pacemaker
  • Having a hypothyroidism, diabetes mellitus, renal/hepatic failure

Treatment and study plan

Ultrasonographic evaluation

Other

Ultrasonographic measurement is assessment method to diagnosis of sarcopenia

Primary outcomes

  1. Muscle thickness

    Time frame: 30 minutes

    Muscle thickness in millimeters by Ultrasound.

  2. Skeletal muscle mass

    Time frame: 2 minutes

    Skeletal muscle mass will be evaluated by bioelectrical impedance analysis.The unit of measure is kg.

Secondary outcomes

  1. Muscle strength

    Time frame: 15 minutes

    Muscle strength will be evaluated using an isokinetic dynamometer (Biodex Medical Systems, New York, USA). Knee and ankle muscle strength( flexion, extension, dorsiflexion and plantarflexion) will be evaluated. The unit of measure is Nm/kg.

  2. Peripheral strength

    Time frame: 1 minutes

    The peripheral (handgrip) strength will be measured with a dynamometer (JAMAR).Three measurements will be taken, whose average of the three measurements will be collected. The unit of measure is kg.

  3. Physical function

    Time frame: 5 minutes

    Physical function will be evaluated by short physical performance scale. The score of this scale range from 0 (worst performance) to 12 (best performance).

  4. Anthropometric assessments

    Time frame: 5 minutes

    Participants waist, hip and calf circumferences will be measured by tape measure. The unit of measure is centimeters.

  5. Balance

    Time frame: 1 minute

    Timed up and go test evaluates dynamic balance of participants. The timed up and go test measures the time that a patient needs to stand up from a chair, walk a 3-m distance, come back and sit back on the chair.Timed up and go test measure is second. The lower values indicates the better balance.

  6. Body mass index

    Time frame: 1 minute

    Participants' weight and height will be evaluated by electronic weighing and tape measure, respectively. body mass index will be expressed in in kg/ m²

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Registry information

Official study title

Cut-off Values and Adjustments for Diagnosing Sarcopenia

Important dates

Study start
2019
Primary completion
2019
Study completion
2019
First posted
Jun 20, 2019
Registry last updated
Aug 13, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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