Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07301905

Culturally Targeted Health Communication and Receptivity to the Human Papillomavirus Vaccine Among Parents in Flint, MI

The goal of this clinical trial is to learn if culturally targeted messaging about the human papillomavirus (HPV) increases receptivity to the HPV vaccine among African American parents of vaccine-eligible daughters. The main question it aims to answer is:

• Does culturally targeted messaging increase African American parents' intentions to vaccinate their daughter against HPV?

Research will compare culturally targeted messaging to general, educational messaging and no messaging.

Participants will:

* View culturally targeted messages, education-only messages, or no messages about the HPV vaccine * Report their intentions to vaccinate their daughter against HPV * Report whether they have initiated HPV vaccination for their daughter six months later

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Flint Journal Building

Flint, Michigan, 48502, United States

Location status: Recruiting

Location contact

About this study

Cervical cancer incidence and mortality are higher for African American women than for White women. The human papillomavirus (HPV) vaccine is the most effective strategy for reducing risk for cervical cancer. However, African American girls are less likely to have completed the HPV vaccine series than White girls. The present research will evaluate a culturally targeted approach to health messaging about the HPV vaccine for parents with vaccine-eligible daughters. The central hypothesis is that African American parents will have greater receptivity to the HPV vaccine after receiving culturally targeted messaging compared to parents who receive no messaging or education-only messaging about HPV vaccination. The primary aims are: 1) evaluate effects of HPV vaccine education on White and African American parents' receptivity to the HPV vaccine, and whether culturally targeted messaging enhances HPV vaccine receptivity among African American parents, 2) compare effects of education-only versus culturally targeted messaging on activation of racism-related thinking when considering child HPV vaccination, and 3) examine the effects of racism-related medical mistrust on the effectiveness of culturally targeted messaging. General and culturally targeted messaging about the HPV vaccine were developed in collaboration with community members and a local health educator. Participants will report their intentions to vaccinate their daughter against HPV immediately after viewing health messaging, as well as initiation of the HPV vaccine series for their daughter 6-months post-messaging.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Identify as Black/African American or White/Caucasian
  • Have at least one daughter who is between 8-17 years of age, who is not currently pregnant, and who has not received any doses of the HPV vaccine

Exclusion criteria

  • N/A

Treatment and study plan

General HPV Vaccine Health Messaging

Behavioral

General, education-only messaging about the HPV vaccine does not include culturally targeted messaging.

Culturally Targeted HPV Vaccine Health Messaging

Behavioral

Educational messaging about the HPV vaccine includes culturally targeted messaging about the HPV vaccine.

Primary outcomes

  1. HPV Vaccine Attitudes

    Time frame: Immediately following and 6-months post-health messaging

    Subscale of Theory of Planned Behavior measuring attitudes toward the HPV vaccine on response scale ranging from 1 = Strongly disagree to 7 = Strongly agree, where higher average scores indicate more positive attitudes

  2. HPV Vaccine Normative Beliefs

    Time frame: Immediately following and 6-months post-health messaging

    Subscale of Theory of Planned Behavior measuring the extent to which participants believe other people are favorable toward the HPV vaccine on response scale ranging from 1 = Strongly disagree to 7 = Strongly agree, where higher average scores indicate stronger normative beliefs

  3. HPV Vaccine Perceived Behavioral Control

    Time frame: Immediately following and 6-months post-health messaging

    Subscale of Theory of Planned Behavior measuring beliefs about ability to vaccinate their child on response scale ranging from 1 = Strongly disagree to 7 = Strongly agree, where higher average scores indicate greater perceived behavioral control

  4. HPV Vaccine Intentions

    Time frame: Immediately following and 6-months post-health messaging

    Subscale of Theory of Planned Behavior measuring intentions to vaccinate their child on response scale ranging from 1 = Strongly disagree to 7 = Strongly agree, where higher average scores indicate greater intentions

  5. Vaccination Initiation

    Time frame: 6-months post-health messaging

    1 self-report item measuring whether parents' daughters have received at least one dose of the HPV vaccine since completion of the initial survey, with Yes/No response options

  6. Vaccination Discussion

    Time frame: 6-months post-health messaging

    1 self-report item measuring whether parents have discussed the HPV vaccine with their daughters' healthcare provider since completion of the initial survey, with Yes/No response options

Secondary outcomes

  1. Anticipatory Racism

    Time frame: Immediately following health messaging

    3 items measuring the extent to which parents expect racism-related factors to interfere with getting the HPV vaccine for their daughter on a 7-point response scale on response scale ranging from 1 = Strongly disagree to 7 = Strongly agree, where higher average scores indicate greater expectations of racism

Study contacts

Contact information is provided by the study sponsor or research team.

Olivia Aspiras, PhD

CONTACT

[email protected]

810-600-9181

Sponsors and collaborators

Lead sponsor

Michigan State University

Other

Registry information

Official study title

Culturally Targeted Messaging and Parental Receptivity to the Human Papillomavirus Vaccine

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Dec 24, 2025
Registry last updated
Mar 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.