Culprit Lesion Only PCI Versus Multivessel PCI in Cardiogenic Shock

Inclusion criteria

Cardiogenic shock complicating acute myocardial infarction (STEMI or NSTEMI) with obligatory:

I) Planned early revascularization by PCI II) Multivessel coronary artery disease defined as more than 70% stenosis in at least 2 major vessels (more than 2 mm diameter) with identifiable culprit lesion III)

• Systolic blood pressure less than 90 mmHg for more than 30 min or
• catecholamines required to maintain pressure more than 90 mmHg during systole and IV) Signs of pulmonary congestion V) Signs of impaired organ perfusion with at least one of the following criteria

a) Altered mental status b) Cold, clammy skin and extremities c) Oliguria with urine output less than 30 ml/h d) Serum-lactate more than 2.0 mmol/l VI) Informed consent

Exclusion criteria

• Resuscitation more than 30 minutes
• No intrinsic heart action
• Cerebral deficit with fixed dilated pupils (not drug-induced)
• Need for primary urgent bypass surgery (to be determined after diagnostic angiography)
• Single vessel disease
• Mechanical cause of cardiogenic shock
• Onset of shock more than 12 h
• Massive lung emboli
• Age more than 90 years
• Shock of other cause (bradycardia, sepsis, hypovolemia, etc.)
• Other severe concomitant disease with limited life expectancy <6 months
• Pregnancy
• Known severe renal insufficiency (creatinine clearance <30 ml/kg)