Skip to main content
OpenTrials
Completed

NCT Number: NCT02074124

CT Perfusion Changes in GI Cancer During Adenosine Vasodilation Test

The aim of this study was to investigate changes in abdominal tissue perfusion during adenosine vasodilation. Our hypotheses were that CT perfusion measurements are altered by changes in the circulatory system mediated by adenosine, and a more differentiated assessment of the circulatory capacity of abdominal tumours could be achieved by sequential rest and adenosine vasodilation CT perfusion measurements.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Esophageal Cancer Digestive System Diseases Digestive System Neoplasms Esophageal Diseases Esophageal Neoplasms Gastric Cancer Gastrointestinal Diseases Gastrointestinal Neoplasms Head and Neck Neoplasms Neoplasms Neoplasms by Site Stomach Diseases Stomach Neoplasms

Age range

40 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Rigshospitalet

Copenhagen, 2100, Denmark

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Tumour larger than 1.5 cm on diagnostic CT
  • Normal serum creatinine
  • Age above 18
  • Informed written and oral consent.

Exclusion criteria

  • Contrast allergy or contrast induced nephropathy
  • BMI > 40
  • Asthma or Chronic Obstructive Lung Disease
  • Heart failure (NYHA III+)
  • Heart conduction disorder
  • Atrial fibrillation
  • 2nd/3rd Heart block
  • Long QT syndrome
  • Wolf Parkinson White Syndrome
  • Moderate / severe aortic stenosis
  • Haemodynamic contraindications for adenosine, systolic pressure below 90

Treatment and study plan

Primary outcomes

  1. Change in arterial flow during adenosine vasodilation test (CT perfusion parameter)

    Time frame: 0 min and 15 min

Secondary outcomes

  1. Change in Blood pressure during adenosine vasodilation test

    Time frame: 0 min and 15 min

  2. Change in Heart rate during adenosine vasodilation test

    Time frame: 0 min and 15 min

  3. Change in Area under arterial input curve during adenosine vasodilation test

    Time frame: 0 min and 15 min

    Area Under Curve (AUC) is correlated to cardiac output

  4. Change in Blood volume (CT perfusion parameter) during adenosine vasodilation test

    Time frame: 0 min and 15 min

  5. Change in Permeability (CT perfusion parameter) during adenosine vasodilation test.

    Time frame: 0 min and 15 min

Sponsors and collaborators

Lead sponsor

University of Copenhagen

Other

Registry information

Official study title

Abdominal Tissue Perfusion Changes in Esophageal and Gastric Cancer During Adenosine Vasodilation Measured With Computed Tomography (CT) Perfusion

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Feb 28, 2014
Registry last updated
Feb 28, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.