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NCT Number: NCT07575763

CT-Guided vs Conventional DLT Sizing in Thoracic Surgery

This is a prospective, randomized, single-blinded controlled trial designed to compare CT-guided versus conventional methods for selecting double-lumen tube (DLT) size in patients undergoing thoracic surgery requiring one-lung ventilation

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Key information

Conditions

Thoracic Surgery One-Lung Ventilation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

King Hussein Cancer Center

Amman, 11941, Jordan

About this study

This is a prospective, randomized, single-blinded controlled trial designed to compare CT-guided versus conventional methods for selecting double-lumen tube (DLT) size in patients undergoing thoracic surgery requiring one-lung ventilation. The study aims to evaluate whether preoperative computed tomography (CT)-based bronchial diameter measurement improves the accuracy of initial DLT size selection compared with conventional selection based on demographic parameters.

Eligible patients will be randomly assigned in a 1:1 ratio to either the CT-guided group or the conventional group.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patients (≥18 years) scheduled for elective thoracic surgery requiring one-lung ventilation.
  • Availability of preoperative thoracic CT imaging.
  • Procedures requiring placement of a left-sided DLT.
  • Patient who has a normal pulmonary function test.

Exclusion criteria

  • Previous tracheal surgery
  • Patient with difficult airway whom need bronchial blocker.
  • Emergency thoracic procedures.
  • Incomplete intraoperative or imaging data.
  • Patient with severe obstruction or restriction.
  • Pediatric patient

Treatment and study plan

CT-Guided Group (Intervention)

Other

Participants will undergo preoperative CT measurement of the bronchial diameter 10 mm distal to the carina. DLT size will be selected using manufacturer-recommended correlation charts based on CT measurements.

Conventional Group (Control)

Other

DLT size will be selected using standard clinical criteria based on patient demographics, including sex, height, and weight, according to institutional standard tables.

Primary outcomes

  1. Successful selection of the correct DLT size on the first attempt (defined as optimal position and lung isolation without the need for tube exchange) using fiberoptic scope

    Time frame: During the intraoperative period (at first attempt of double-lumen tube placement)

    the correct placement of a double-lumen tube (DLT) on the first attempt, achieving optimal tracheobronchial position and effective lung isolation as confirmed by fiberoptic bronchoscopy, without the need for tube exchange or repositioning.

Secondary outcomes

  1. Incidence of DLT replacement

    Time frame: Intraoperative period (from initial DLT placement until end of surgery)

    Number of participants requiring replacement of the double-lumen tube (DLT) after initial placement due to incorrect size, malposition, or inadequate lung isolation

  2. Time required for successful intubation

    Time frame: Intraoperative period (from DLT insertion to confirmed successful placement)

    Time (in seconds) from insertion of the double-lumen tube into the mouth until successful tracheal placement and confirmation of correct positioning and lung isolation

  3. Frequency of intraoperative hypoxia and peak airway pressure fluctuations

    Time frame: Intraoperative period (from DLT insertion to confirmed successful placement)

    Incidence of episodes of intraoperative hypoxia and measurement of peak airway pressure fluctuations during one-lung ventilation.

  4. Blinded assessment of surgeon satisfaction (lung isolation quality)

    Time frame: At the end of surgery (intraoperative assessment)

    Surgeon satisfaction with lung isolation quality assessed using a standardized scoring scale, evaluated in a blinded manner at the end of the surgical procedure.

  5. Post-operative sore throat or airway trauma

    Time frame: 24 hours post-extubation

    Incidence and severity of post-operative sore throat and/or signs of airway trauma (e.g., hoarseness, blood on suctioning, or mucosal injury if assessed) within 24 hours after extubation.

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmad Al Kharabsheh, Fellow physician

CONTACT

[email protected]

00962-796420055

Moh'D Yousef, Consultant

CONTACT

[email protected]

+962796420055

Sponsors and collaborators

Lead sponsor

King Hussein Cancer Center

Other

Registry information

Official study title

CT-Guided Versus Traditional Selection of Double-Lumen Tube Size for One-Lung Ventilation in Thoracic Surgery: A Prospective Study

Acronym: CTDLT-SIZE

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
May 8, 2026
Registry last updated
May 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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