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NCT Number: NCT05433467

CT-guided Localization for Micro Hepatocellular Carcinoma Before Surgical Resection

In this project, the preoperative anatomical location of micro hepatocellular carcinoma under the guidance of CT can provide guidance for accurate surgical resection. It may also shorten the operation time and reduce intraoperative bleeding.

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Key information

Conditions

Cirrhosis, Liver Adenocarcinoma Carcinoma Carcinoma, Hepatocellular Digestive System Diseases Digestive System Neoplasms Fibrosis Hepatocellular Carcinoma Liver Cirrhosis Liver Diseases Liver Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

About this study

General and basic information of the patients included in the study was collected. After preoperative preparation was completed, on the day of surgery, disposable pulmonary nodular localization needle (Ningbo Sonjiecang Biological Technology Co., LTD., Model: SS510-10) was used for the localization of micro hepatocellular carcinoma that could be found by preoperative CT enhancement or MRI. After the micro hepatocellular carcinoma was located under the guidance of CT, and then the patient was sent to the operating room. During the operation, the lesion was removed according to the tail line of the positioning needle and the position of the positioning needle.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Be at least 18 years old and give informed consent to participate in the study
  • A preoperative (clinical, radiological, or histological) diagnosis of cirrhosis of the liver due to any cause.
  • micro hepatocellular carcinoma (diameter less than 1cm).
  • Preoperative CT plain scan could not find the lesion, and preoperative B-ultrasound could not find the lesion.
  • Preoperative CT enhancement or MRI can detect the lesion.

Exclusion criteria

  • Child-Pugh grade C
  • Uncontrolled Hypertension
  • Severe lung dysfunction
  • Severe cardiac dysfunction

Treatment and study plan

CT-guided localization for micro hepatocellular carcinoma before surgical resection

Procedure

After preoperative preparation was completed, on the day of surgery, disposable pulmonary nodular localization needle (Ningbo Sonjiecang Biological Technology Co., LTD., Model: SS510-10) was used for the localization of micro hepatocellular carcinoma that could be found by preoperative CT enhancement or MRI. After the micro hepatocellular carcinoma was located under the guidance of CT, and then the patient was sent to the operating room. During the operation, the lesion was removed according to the tail line of the positioning needle and the position of the positioning needle.

Primary outcomes

  1. The position of the needle

    Time frame: During operation

    The distance (mm) of the needle to the edge of hepatocellular carcinoma

Secondary outcomes

  1. Operation time

    Time frame: During operation

    The length of operation time (min)

  2. Intraoperative bleeding

    Time frame: During operation

    The volume of intraoperative bleeding (ml)

Study contacts

Contact information is provided by the study sponsor or research team.

Dou-Sheng Bai, MD

CONTACT

[email protected]

+8651487373382

Guo-Qing Jiang, MD

CONTACT

[email protected]

+8651487373382

Sponsors and collaborators

Lead sponsor

Northern Jiangsu People's Hospital

Other

Registry information

Official study title

The Feasibility of CT-guided Localization for Micro Hepatocellular Carcinoma Before Surgical Resection

Acronym: CTMH

Important dates

Study start
2022
Primary completion
2026
Study completion
2026
First posted
Jun 27, 2022
Registry last updated
Aug 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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