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OpenTrials
Completed

NCT Number: NCT01189331

CT Coronary Angiography and Computational Fluid Dynamics

Angiographically obtained fractional flow reserve(FFR) could provide functional and clinical information about stenotic lesion, but the invasiveness and measuring difficulty of FFR make it unfamiliar to perform. CT coronary angiography is non-invasive tool to evaluate lesion severity and lately developing computational fluid dynamics could provide functional information. The investigators build a patient specific model of computational fluid dynamics by CT coronary angiography and evaluate the functional significance by measuring fractional flow reserve via CT coronary angiography and computational fluid dynamics, and investigate its long-term prognostic implications.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Seoul National University Hospital

Seoul, 110744, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Significant stenosis at CT angiography
  • Normal ejection fraction on echocardiography
  • Informed consented patient

Exclusion criteria

  • total occlusion and collateral flow to target vessel
  • AV conduction abnormality
  • Left ventricular hypertrophy
  • significant valvular heart or primary myocardial disease

Treatment and study plan

CT coronary angiography and computational fluid dynamics

Device

Evaluate coronary blood flow dynamics by CT coronary angiography and computational fluid dynamics

Primary outcomes

  1. fractional flow reserve

    Time frame: 1day

    fractional flow reserve of stenotic coronary artery

  2. target vessel failure

    Time frame: 10 year

    composite of cardiovascular death, target vessel myocardial infarction, target vessel revascularization

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Collaborators

  • Cornell University
  • Indiana University
  • Inje University
  • Pauls Stradins Clinical University Hospital
  • Stanford University
  • Ulsan university

Registry information

Official study title

Non-invasive Functional Assessment of Coronary Stenoses Using CT Coronary Angiography and Computational Fluid Dynamics

Important dates

Study start
2009
Primary completion
2020
Study completion
2020
First posted
Aug 26, 2010
Registry last updated
Mar 16, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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