CT Based Definition of a Tissue Window for Acute Stroke Thrombolysis

Aim of this study is to define a CT-based "tissue window" for stroke thrombolysis. Our primary hypothesis is that

1. patients with a "tissue window" (favourable non-contrast CT (NCCT) scan and an intracranial occlusion on CT angiography (CTA) or perfusion-CT-mismatch" (area of reduced cerebral blood flow (CBF) > area of reduced cerebral blood volume (CBV)) represent a significant proportion (> 20%)of acute stroke patients and therefore are an important target group for future interventional studies 2. patients with a "tissue window" suffer an unfavourable outcome (> 50 % mRS =>4 at 3 months)if the occluded artery was not recanalized.

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Key information

Conditions

Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Ischemic Stroke Nervous System Diseases Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Dresden, Dept of Neurology

Dresden, 01307, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

ischemic anterior circulation stroke
last seen normal < 12 hours
stroke severity => 3 on the National Institute of Health Stroke Scale
multimodal CT stroke protocol performed
informed consent obtained

Exclusion criteria

premorbid modified Rankin Scale score > 3
contraindications to contrast media application
pregnancy or breast feeding
subacute stroke > 50 % of MCA territory
CT evidence of non-vascular cause of stroke symptoms

Treatment and study plan

Primary outcomes

modified Rankin Scale scores 0-2

Time frame: 90 days

Sponsors and collaborators

Lead sponsor

Technische Universität Dresden

Other

Registry information

Official study title

Observational Study of Multimodal CT in Acute Ischemic Stroke to Define a Tissue Window for Thrombolysis

Acronym: CT-DEFINE

Important dates

Study start: 2007
Primary completion: 2008
Study completion: 2009
First posted: Apr 20, 2007
Registry last updated: May 14, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed