Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07341490

CT-Angiography Versus Angiogram as Ancillary Tests in the Determination of Death by Neurologic Criteria

Diagnostic performance of a novel protocol for computed tomography-angiography, as ancillary test in the determination of complete cerebral infarction, in comparison to four vessel angiography.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Infarction, Brain Brain Death Brain Diseases Brain Infarction Brain Ischemia Cardiovascular Diseases Central Nervous System Diseases Cerebral Infarction Cerebrovascular Disorders Coma Consciousness Disorders Death Infarction Ischemia Necrosis Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathologic Processes Pathological Conditions, Signs and Symptoms Stroke Unconsciousness Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults 18 years or older
  • Ongoing critical care due to severe acute brain injury
  • Four vessel angiography necessary for the determination of complete cerebral infarction, according to Swedish legislation

Exclusion criteria

  • Treatment with extracorporeal membrane oxygenation (ECMO)
  • Radiologic examination by computed tomography deemed too challenging due to respiratory or circulatory instability, as determined by responsible clinician

Treatment and study plan

Primary outcomes

  1. Diagnostic performance similar between computed tomography-angiography and four vessel angiography

    Time frame: Periprocedural

    Sensitivity, specificity, positive predictive value, negative predictive value, inter- and intrarater variability.

Study contacts

Contact information is provided by the study sponsor or research team.

Anja Rosén, M.D.

CONTACT

[email protected]

+46-8-12370000 ext. 94856

Peter C Rudberg, M.D. Ph.D.

CONTACT

[email protected]

+46-8-1237000 ext. 72341

Sponsors and collaborators

Lead sponsor

Region Stockholm

Other Gov

Collaborators

  • Karolinska Institutet

Registry information

Official study title

A Comparison of Computed Tomography-Angiography Versus Four-vessel Angiography in the Determination of Brain Death

Acronym: Tadaa

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Jan 14, 2026
Registry last updated
Mar 17, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.