CT Abnormalities Evocative of Lung Infection Are Associated With Lower 18F-FDG Uptake in Confirmed COVID-19 Patients

CT signs that are evocative of lung COVID-19 infections have been extensively described, whereas 18F-FDG-PET signs have not. Our current study aimed to identify specific COVID-19 18F-FDG-PET signs in patients that were (i) suspected to have a lung infection based on 18F-FDG-PET/CT recorded during the COVID-19 outbreak and (ii) whose COVID-19 diagnosis was definitely established or excluded by appropriate viral testing.

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Key information

Conditions

Presence of COVID-19 Compatible CT Abnormalities COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHRU of Nancy

Vandœuvre-lès-Nancy, Grand Est, 54511, France

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient coming to nuclear medicine for 18F-flurodesoxyglucose (FDG) positron emission tomography computed tomography (PET-CT) with suspicion of lung involvement
patient affiliated to a social security scheme or equivalent
adult patient having been informed of the study

Exclusion criteria

patient with a negative covid 19 test

Treatment and study plan

PET-CT of 18F-FDG

Diagnostic Test

Whole-body 18F-FDG-PET/CT was performed on a digital hybrid system (Vereos, Philips®)

Primary outcomes

Visual analysis of pulmonary lobes

Time frame: 1 day

Visual analysis of the pulmonary lobes by calculating a extent score for each patient

Secondary outcomes

Measurement of metabolic activity

Time frame: 1 day

Measurement of metabolic activity with SUV max of lung areas with CT abnormalities

Sponsors and collaborators

Lead sponsor

Central Hospital, Nancy, France

Other

Registry information

Important dates

Study start: 2020
Primary completion: 2020
Study completion: 2020
First posted: Aug 13, 2020
Registry last updated: Jun 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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