Cryotherapy Versus Dexamethasone on Postoperative Pain in Permanent Mandibular Molars

The goal of this clinical trial was to evaluate cryotherapy versus dexamethasone on the intensity of postoperative pain in root canal treatment procedures in mandibular first molar teeth with symptomatic irreversible pulpitis. The main question it aims to answer is:

* Does controlled irrigation with cold saline in root canal treatment reduce the severity of postoperative pain? * Does controlled irrigation with dexamethasone in root canal treatment reduce the severity of postoperative pain? In the cryotherapy group, unlike the control and dexamethasone group, the root canals were irrigated with 2 °C salin solution in final irrigation.

In the dexamethasone group, unlike the control and cryotherapy group, the root canals were irrigated with 1 mL dexamethasone solution in final irrigation.

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Key information

Conditions

Pulpitis - Irreversible Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cukurova University

Adana, Sarıçam, 01250, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Vital mandibular first and second molars with 3 root canals that responded positively to the cold test and electric pulp test
Patients who had not taken analgesics or antibiotics in the last 24 hours before the procedure were included in the study.

Exclusion criteria

Devital mandibular first and second molars that responded negatively to cold tests and electric pulp tests
Mandibular first and second molars with poor periodontal status (pocket depth > 4 mm),
Mandibular first and second molars with 4 or more root canals detected radiographically or after opening the endodontic access cavity were excluded from the study.

Treatment and study plan

Cryotherapy

Other

The root canals were irrigated with 2 °C saline solution in final irrigation in cryotherapy group.

Dexamethasone

Drug

Each root canal was irrigated with 1 mL dexamethasone solution in final irrigation in dexamethasone group.

Primary outcomes

Visual Analogue Scale

Time frame: up to 72 hours

The visual analog scale for pain is a straight line with one end meaning no pain (0) and the other end meaning the worst pain (10) imaginable. A patient marks a point on the line that matches the amount of pain he or she feels. It may be used to help choose the right dose of pain medicine. Also called VAS.

Sponsors and collaborators

Lead sponsor

Cukurova University

Other

Registry information

Official study title

Effectiveness of Cryotherapy Versus Dexamethasone on Reducing Postoperative Pain in Permanent Mandibular Molars with Irreversible Pulpitis: a Randomized Controlled Clinical Trial

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2025
First posted: Feb 18, 2025
Registry last updated: Mar 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed