Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain

The goal of this Registry is to see how the device is used when freezing nerves during an amputation procedure.

Recruiting

Interested in participating?

Key information

Conditions

Amputation Amputation of Lower Limb Amputation of Upper Limb Amputation, Limb Loss Amputation, Traumatic/Surgery Cryo Analgesia

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Berkshire Medical Center, Pittsfield, Massachusetts, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who have or will have an amputation procedure;
Patients who are willing and capable of providing informed consent;
Patients whose age is 18 years or above, or of legal age to give informed consent specific to state and national law.

Exclusion criteria

Women of childbearing potential who are, or plan to become, pregnant during the time of the study;
Other medical, social, or psychological conditions that in the opinion of the Investigator precludes the subject from appropriate consent or adherence to the protocol.

Treatment and study plan

Cryoablation

Device

Cryoanalgesia, also known as Cryoablation, Cryoneurolysis, or Cryonerve Block, has been used for decades to treat chronic pain and has recently been employed for the management of Phantom Limb Pain. Cryoanalgesia involves the use of a probe to apply extreme cold (approximately -70◦C) to induce reversible axonal injury and Wallerian degeneration to produce a temporary conduction block that is sustained until regeneration of the axon and sensation is restored, typically weeks to months later.

Primary outcomes

Primary Outcome Measure

Time frame: 30 days

CryoNerve Block procedural complications

Study contacts

Contact information is provided by the study sponsor or research team.

Senior Registry Specialist

CONTACT

[email protected]

1 (866) 349-2342

Sponsors and collaborators

Lead sponsor

AtriCure, Inc.

Industry

Registry information

Official study title

Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain (VANISH)

Acronym: VANISH

Important dates

Study start: 2025
Primary completion: 2035
Study completion: 2035
First posted: Apr 3, 2025
Registry last updated: Jun 26, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Recruiting